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Literature DB >> 7530933

Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures.

P K Peterson¹, G Gekker, S Hu, C C Chao.

Abstract

Antiviral activities of the reverse transcriptase inhibitors U-90152 and 3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active.

Entities: Chemical Disease Species

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Year: 1994 PMID： 7530933 PMCID： PMC284764 DOI： 10.1128/AAC.38.10.2465

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

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3 in total