Literature DB >> 2193094

Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms.

G Poli1, P Bressler, A Kinter, E Duh, W C Timmer, A Rabson, J S Justement, S Stanley, A S Fauci.   

Abstract

The immunoregulatory cytokine interleukin 6 (IL-6) directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage. In addition, IL-6 synergizes with tumor necrosis factor alpha (TNF-alpha) in the induction of latent HIV expression. Unlike TNF-alpha, upregulation of viral expression induced by IL-6 alone does not occur at the transcriptional level and it is not associated with accumulation of HIV RNA. However, when IL-6 and TNF-alpha synergistically stimulate HIV production, accumulation of HIV RNA and increased transcription are observed, indicating that IL-6 affects HIV expression at multiple (transcriptional and post-transcriptional) levels.

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Year:  1990        PMID： 2193094      PMCID： PMC2188185          DOI： 10.1084/jem.172.1.151

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  34 in total

1.  Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors:  A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

2.  Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.

Authors:  T Folks; J Kelly; S Benn; A Kinter; J Justement; J Gold; R Redfield; K W Sell; A S Fauci
Journal:  J Immunol       Date:  1986-06-01       Impact factor: 5.422

3.  Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Authors:  J Gauldie; C Richards; D Harnish; P Lansdorp; H Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

4.  A macrophage-derived factor required by plasmacytomas for survival and proliferation in vitro.

Authors:  R P Nordan; M Potter
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

5.  Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

Authors:  T M Folks; J Justement; A Kinter; C A Dinarello; A S Fauci
Journal:  Science       Date:  1987-11-06       Impact factor: 47.728

6.  T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.

Authors:  A Muraguchi; T Kishimoto; Y Miki; T Kuritani; T Kaieda; K Yoshizaki; Y Yamamura
Journal:  J Immunol       Date:  1981-08       Impact factor: 5.422

7.  Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

Authors:  G Poli; A Kinter; J S Justement; J H Kehrl; P Bressler; S Stanley; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

8.  Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.

Authors:  G Haegeman; J Content; G Volckaert; R Derynck; J Tavernier; W Fiers
Journal:  Eur J Biochem       Date:  1986-09-15

9.  Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.

Authors:  A Zilberstein; R Ruggieri; J H Korn; M Revel
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598

10.  Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

Authors:  J Van Damme; G Opdenakker; R J Simpson; M R Rubira; S Cayphas; A Vink; A Billiau; J Van Snick
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307
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  159 in total

1.  Levels of proinflammatory cytokines in plasma after pneumoccoccal immunization in human immunodeficiency virus type 1-infected patients.

Authors:  H Valdez; S Purvis; R Asaad; I Valerio; B E Sha; A L Landay; M M Lederman
Journal:  Clin Diagn Lab Immunol       Date:  1999-05

2.  Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission.

Authors:  Surender B Kumar; Cara E Rice; Danny A Milner; Nilsa C Ramirez; William E Ackerman; Victor Mwapasa; Abigail Norris Turner; Jesse J Kwiek
Journal:  AIDS       Date:  2012-03-27       Impact factor: 4.177

3.  T-cell-receptor dose and the time of treatment during murine retrovirus infection for maintenance of immune function.

Authors:  B Liang; S Ardestani; J J Marchalonis; R R Watson
Journal:  Immunology       Date:  1996-02       Impact factor: 7.397

Review 4.  Regulation of HIV-1 transcription.

Authors:  K A Roebuck; M Saifuddin
Journal:  Gene Expr       Date:  1999

5.  Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with maedi-visna virus and stimulates maedi-visna virus replication in macrophages in vitro.

Authors:  Z Zhang; G D Harkiss; J Hopkins; C J Woodall
Journal:  Clin Exp Immunol       Date:  2002-08       Impact factor: 4.330

6.  Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani.

Authors:  R Bernier; S J Turco; M Olivier; M Tremblay
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

7.  Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.

Authors:  K A Qatsha; C Rudolph; D Marmé; C Schächtele; W S May
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

8.  A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells.

Authors:  D Weissman; G Poli; A Bousseau; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

9.  Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens.

Authors:  M Denis; E Ghadirian
Journal:  Clin Exp Immunol       Date:  1994-07       Impact factor: 4.330

10.  Chronic HIV Infection Is Associated with Upregulation of Proinflammatory Cytokine and Chemokine and Alpha Defensin Gene Expression in Colorectal Mucosa.

Authors:  Jennifer Mait-Kaufman; Esra Fakioglu; Pedro M M Mesquita; Julie Elliott; Yungtai Lo; Rebecca Pellett Madan
Journal:  AIDS Res Hum Retroviruses       Date:  2015-04-08       Impact factor: 2.205
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