Literature DB >> 7530665

Novel assay for the influenza virus M2 channel activity.

K Giffin1, R K Rader, M H Marino, R W Forgey.   

Abstract

The influenza A M2 ion channel was expressed and activity characterized in Xenopus oocytes. Based on the activation properties of the channels, a high throughput, non-electrophysiological screening assay was developed in order to identify novel inhibitors of the channel. This will facilitate discovery of novel agents to treat influenza viral infections.

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Year:  1995        PMID： 7530665     DOI： 10.1016/0014-5793(94)01369-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus.

Authors:  K Tobler; M L Kelly; L H Pinto; R A Lamb
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

Review 2.  Ion channels as antivirus targets.

Authors:  Xin Liang; Zhi-Yuan Li
Journal:  Virol Sin       Date:  2010-07-28       Impact factor: 4.327

3.  Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue.

Authors:  C Wang; R A Lamb; L H Pinto
Journal:  Biophys J       Date:  1995-10       Impact factor: 4.033

4.  Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus.

Authors:  Q Tu; L H Pinto; G Luo; M A Shaughnessy; D Mullaney; S Kurtz; M Krystal; R A Lamb
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

5.  Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.

Authors:  Jun Wang; Sarah D Cady; Victoria Balannik; Lawrence H Pinto; William F DeGrado; Mei Hong
Journal:  J Am Chem Soc       Date:  2009-06-17       Impact factor: 15.419

Review 6.  Anti-influenza virus agents: synthesis and mode of action.

Authors:  Irene M Lagoja; Erik De Clercq
Journal:  Med Res Rev       Date:  2008-01       Impact factor: 12.944

7.  A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus.

Authors:  Jian-Ping Dai; Wei-Zhong Li; Xiang-Feng Zhao; Ge-Fei Wang; Jia-Cai Yang; Lin Zhang; Xiao-Xuan Chen; Yan-Xuan Xu; Kang-Sheng Li
Journal:  PLoS One       Date:  2012-08-10       Impact factor: 3.240

8.  Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

Authors:  Aruna D Balgi; Jun Wang; Daphne Y H Cheng; Chunlong Ma; Tom A Pfeifer; Yoko Shimizu; Hilary J Anderson; Lawrence H Pinto; Robert A Lamb; William F DeGrado; Michel Roberge
Journal:  PLoS One       Date:  2013-02-01       Impact factor: 3.240
  8 in total

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