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Literature DB >> 7529757

Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa.

S Bacci¹, R Arbi-Riccardi, B Mayer, C Rumio, M B Borghi-Cirri.

Abstract

Nitric oxide (NO)-synthase immunoreactivity has been detected for the first time in mast cells of human normal nasal mucosa, with an antibody specific for neuronal NO-synthase. Intense immunoreactivity was revealed in secretion granules of mast cells but was found in mast cell granules free in the extracellular matrix only in some instances; no reactivity was found in the cytoplasm of this or other cell types. These findings suggest that human nasal mast cells contain a particulate isoform of NO-synthase, which shares epitopes with neuronal NO-synthase and is rapidly removed from granules upon exocytosis.

Entities: Chemical Species

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Year: 1994 PMID： 7529757 DOI： 10.1007/bf00269011

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

13 in total

1. Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the guinea-pig.

Authors: W Kummer; A Fischer; P Mundel; B Mayer; B Hoba; B Philippin; U Preissler
Journal: Neuroreport Date: 1992-07 Impact factor: 1.837

Review 2. Isoforms of nitric oxide synthase. Characterization and purification from different cell types.

Authors: U Förstermann; H H Schmidt; J S Pollock; H Sheng; J A Mitchell; T D Warner; M Nakane; F Murad
Journal: Biochem Pharmacol Date: 1991-10-24 Impact factor: 5.858

3. Mast cells as a source of superoxide anions and nitric oxide-like factor: relevance to histamine release.

Authors: P F Mannaioni; E Masini; A Pistelli; D Salvemini; J R Vane
Journal: Int J Tissue React Date: 1991

4. Conjugated avidin binds to mast cell granules.

Authors: M D Tharp; L L Seelig; R E Tigelaar; P R Bergstresser
Journal: J Histochem Cytochem Date: 1985-01 Impact factor: 2.479

5. A study on morphological changes and histamine release induced by compound 48/80 in rat peritoneal mast cells.

Authors: G D Bloom; O Haegermark
Journal: Exp Cell Res Date: 1965-12 Impact factor: 3.905

6. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Authors: U Förstermann; J S Pollock; H H Schmidt; M Heller; F Murad
Journal: Proc Natl Acad Sci U S A Date: 1991-03-01 Impact factor: 11.205

7. Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide.

Authors: T Bandaletova; I Brouet; H Bartsch; T Sugimura; H Esumi; H Ohshima
Journal: APMIS Date: 1993-04 Impact factor: 3.205

Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa.

1. Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the guinea-pig.

Review 2. Isoforms of nitric oxide synthase. Characterization and purification from different cell types.

3. Mast cells as a source of superoxide anions and nitric oxide-like factor: relevance to histamine release.

4. Conjugated avidin binds to mast cell granules.

5. A study on morphological changes and histamine release induced by compound 48/80 in rat peritoneal mast cells.

6. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

7. Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide.

Review 8. Nitric oxide as a secretory product of mammalian cells.

9. Vascular endothelial cells synthesize nitric oxide from L-arginine.

10. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.

1. Mast cells migrate from blood to brain.

2. Interferon-gamma regulates the interaction of RBL-2H3 cells with fibronectin through production of nitric oxide.

Review 3. Role of nitric oxide in mast cells: controversies, current knowledge, and future applications.

4. Nasal hyperreactivity and inflammation in allergic rhinitis.