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Literature DB >> 7529675

Effect of capsaicin on release of substance P-like immunoreactivity from vascularly perfused rat duodenum.

Abstract

The release of substance P-like immunoreactivity (SPLI) from the rat duodenum was investigated using an in situ vascularly perfused preparation. Results show that the basal release of SPLI was measurable and significantly enhanced by the administration of both 1,3, and 10 microM of capsaicin, indicating that SPLI is present in capsaicin-sensitive afferent nerve fibers. It is concluded that the present model may be useful for the study of the control of duodenal release of SPLI.

Entities: Chemical Species

Mesh：

Substances：
Substance P
Capsaicin

Year: 1995 PMID： 7529675 DOI： 10.1007/bf02063949

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

20 in total

1. Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum.

Authors: M Fujimiya; C H McIntosh; H Kimura; Y N Kwok
Journal: Neurosci Lett Date: 1992-10-12 Impact factor: 3.046

Review 2. Search for a physiological role of substance P in gastrointestinal motility.

Authors: L Barthó; P Holzer
Journal: Neuroscience Date: 1985-09 Impact factor: 3.590

3. Effect of capsaicin on gastric corpus smooth muscle of the rat in vitro.

Authors: U Holzer-Petsche; H Seitz; F Lembeck
Journal: Eur J Pharmacol Date: 1989-03-14 Impact factor: 4.432

4. Release of substance P-like immunoreactivity from the vascularly perfused rat stomach.

Authors: Y N Kwok; C H McIntosh
Journal: Eur J Pharmacol Date: 1990-05-16 Impact factor: 4.432

5. Capsaicin-induced release of neurokinin A from muscle and mucosa of gastric corpus: correlation with capsaicin-evoked release of calcitonin gene-related peptide.

Authors: D Renzi; S Evangelista; P Mantellini; P Santicioli; C A Maggi; P Geppetti; C Surrenti
Journal: Neuropeptides Date: 1991-07 Impact factor: 3.286

6. Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.

Authors: P Holzer; P H Guth
Journal: Circ Res Date: 1991-01 Impact factor: 17.367

Effect of capsaicin on release of substance P-like immunoreactivity from vascularly perfused rat duodenum.

1. Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum.

Review 2. Search for a physiological role of substance P in gastrointestinal motility.

3. Effect of capsaicin on gastric corpus smooth muscle of the rat in vitro.

4. Release of substance P-like immunoreactivity from the vascularly perfused rat stomach.

5. Capsaicin-induced release of neurokinin A from muscle and mucosa of gastric corpus: correlation with capsaicin-evoked release of calcitonin gene-related peptide.

6. Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.

7. Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer.

8. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons.

9. Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum.

10. Intestinal peristalsis associated with release of immunoreactive substance P.

1. Acid-induced mesenteric hyperemia in rats: role of CGRP, substance P, prostaglandin, adenosine, and histamine.