Literature DB >> 3948925

Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum.

C A Maggi, P Santicioli, S Manzini, A Meli.   

Abstract

Capsaicin induces a transient relaxation of the isolated rat duodenum in the presence of atropine plus guanethidine. The relaxant effect of capsaicin was not observed in vitro in the duodenum of capsaicin-pretreated animals. Capsaicin-induced relaxation was antagonized by tetrodotoxin or cold storage (24 h at 4 degrees C). It is concluded that capsaicin produces a neurogenic relaxation of the rat duodenum by activating an intramural non-adrenergic non-cholinergic mechanism which inhibits intestinal motility.

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Year:  1986        PMID： 3948925     DOI： 10.1016/0014-2999(86)90480-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  Non-electrical functions of neurons.

Authors:  O S Sotnikov
Journal:  Neurosci Behav Physiol       Date:  2002 Sep-Oct

2.  Effect of capsaicin on release of substance P-like immunoreactivity from vascularly perfused rat duodenum.

Authors:  M Fujimiya; Y N Kwok
Journal:  Dig Dis Sci       Date:  1995-01       Impact factor: 3.199

3.  Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.

Authors:  H Moritoki; T Iwamoto; J Kanaya; Y Ishida; K Ando; K Kitagawa
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

4.  Effect of vanilloid drugs on gastrointestinal transit in mice.

Authors:  A A Izzo; R Capasso; L Pinto; G Di Carlo; N Mascolo; F Capasso
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

5.  The motor response to ethylenediamine of the rat isolated duodenum: involvement of GABAergic transmission?

Authors:  C A Maggi; S Giuliani; P Santicioli; S Selleri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

6.  Four motor effects of capsaicin on guinea-pig distal colon.

Authors:  C A Maggi; A Meli; P Santicioli
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

7.  Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons.

Authors:  C A Maggi; S Manzini; S Giuliani; P Santicioli; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-10       Impact factor: 3.000

8.  A pharmacological and immunohistochemical study of the splanchnic innervation of ileal longitudinal muscle in the toad Bufo marinus.

Authors:  P Osborne; G Campbell
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-10       Impact factor: 3.000
  8 in total

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