Literature DB >> 7529404

Modified RNA sequence pools for in vitro selection.

Y Lin1, Q Qiu, S C Gill, S D Jayasena.   

Abstract

We report the use of modified RNA, in which the 2'-OH group of pyrimidines is replaced by a 2'-amino (2'-NH2) group to identify high affinity ligands specific for human neutrophil elastase (HNE) by in vitro selection. Compared to unmodified RNA the 2'-NH2-modified RNA ligands show enhanced stability in human serum and urine. Use of RNase T1 cleavage data in the presence of K+ and Li+ ions suggests that the modified RNA ligands selected for HNE form an intermolecular G-quartet structure.

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Year:  1994        PMID： 7529404      PMCID： PMC332065          DOI： 10.1093/nar/22.24.5229

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  38 in total

1.  Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.

Authors:  C Tuerk; L Gold
Journal:  Science       Date:  1990-08-03       Impact factor: 47.728

2.  In vitro selection of RNA molecules that bind specific ligands.

Authors:  A D Ellington; J W Szostak
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

3.  SELEXION. Systematic evolution of ligands by exponential enrichment with integrated optimization by non-linear analysis.

Authors:  D Irvine; C Tuerk; L Gold
Journal:  J Mol Biol       Date:  1991-12-05       Impact factor: 5.469

4.  HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.

Authors:  D P Bartel; M L Zapp; M R Green; J W Szostak
Journal:  Cell       Date:  1991-11-01       Impact factor: 41.582

5.  Selection of single-stranded DNA molecules that bind and inhibit human thrombin.

Authors:  L C Bock; L C Griffin; J A Latham; E H Vermaas; J J Toole
Journal:  Nature       Date:  1992-02-06       Impact factor: 49.962

6.  Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops.

Authors:  W I Sundquist; A Klug
Journal:  Nature       Date:  1989-12-14       Impact factor: 49.962

7.  A sodium-potassium switch in the formation of four-stranded G4-DNA.

Authors:  D Sen; W Gilbert
Journal:  Nature       Date:  1990-03-29       Impact factor: 49.962

8.  Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Authors:  M A Navia; B M McKeever; J P Springer; T Y Lin; H R Williams; E M Fluder; C P Dorn; K Hoogsteen
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

9.  Primary structure of human neutrophil elastase.

Authors:  S Sinha; W Watorek; S Karr; J Giles; W Bode; J Travis
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

10.  Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes.

Authors:  W A Pieken; D B Olsen; F Benseler; H Aurup; F Eckstein
Journal:  Science       Date:  1991-07-19       Impact factor: 47.728
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  52 in total

1.  Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity.

Authors:  S E Lee; A Sidorov; T Gourlain; N Mignet; S J Thorpe; J A Brazier; M J Dickman; D P Hornby; J A Grasby; D M Williams
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

2.  Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX.

Authors:  Axel Vater; Florian Jarosch; Klaus Buchner; Sven Klussmann
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

Review 3.  Nucleic acid aptamers: clinical applications and promising new horizons.

Authors:  X Ni; M Castanares; A Mukherjee; S E Lupold
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

4.  Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling.

Authors:  William M Rockey; Frank J Hernandez; Sheng-You Huang; Song Cao; Craig A Howell; Gregory S Thomas; Xiu Ying Liu; Natalia Lapteva; David M Spencer; James O McNamara; Xiaoqin Zou; Shi-Jie Chen; Paloma H Giangrande
Journal:  Nucleic Acid Ther       Date:  2011-10       Impact factor: 5.486

Review 5.  In vitro selection using modified or unnatural nucleotides.

Authors:  Scott M Knudsen; Michael P Robertson; Andrew D Ellington
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2002-02

6.  Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry.

Authors:  K A Davis; Y Lin; B Abrams; S D Jayasena
Journal:  Nucleic Acids Res       Date:  1998-09-01       Impact factor: 16.971

7.  Alignment editing and identification of consensus secondary structures for nucleic acid sequences: interactive use of dot matrix representations.

Authors:  J P Davis; N Janjić; D Pribnow; D A Zichi
Journal:  Nucleic Acids Res       Date:  1995-11-11       Impact factor: 16.971

8.  High-affinity and specific recognition of human thyroid stimulating hormone (hTSH) by in vitro-selected 2'-amino-modified RNA.

Authors:  Y Lin; D Nieuwlandt; A Magallanez; B Feistner; S D Jayasena
Journal:  Nucleic Acids Res       Date:  1996-09-01       Impact factor: 16.971

9.  Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.

Authors:  Y Lin; A Padmapriya; K M Morden; S D Jayasena
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  RNA ligands to human nerve growth factor.

Authors:  J Binkley; P Allen; D M Brown; L Green; C Tuerk; L Gold
Journal:  Nucleic Acids Res       Date:  1995-08-25       Impact factor: 16.971
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