Literature DB >> 1697402

In vitro selection of RNA molecules that bind specific ligands.

A D Ellington1, J W Szostak.   

Abstract

Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.

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Year:  1990        PMID： 1697402     DOI： 10.1038/346818a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  2000 in total

1.  In vitro selection of RNAs with increased tertiary structure stability.

Authors:  K Juneau; T R Cech
Journal:  RNA       Date:  1999-08       Impact factor: 4.942

2.  SELEX_DB: an activated database on selected randomized DNA/RNA sequences addressed to genomic sequence annotation.

Authors:  J V Ponomarenko; G V Orlova; M P Ponomarenko; S V Lavryushev; A S Frolov; S V Zybova; N A Kolchanov
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

3.  Estimation of SELEX pool size by measurement of DNA renaturation rates.

Authors:  J Charlton; D Smith
Journal:  RNA       Date:  1999-10       Impact factor: 4.942

4.  mRNA display: diversity matters during in vitro selection.

Authors:  L Gold
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

5.  RNAs that bind and change the permeability of phospholipid membranes.

Authors:  A Khvorova; Y G Kwak; M Tamkun; I Majerfeld; M Yarus
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

6.  RNA aptamers as effective protein antagonists in a multicellular organism.

Authors:  H Shi; B E Hoffman; J T Lis
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

Review 7.  [Aptamers: a novel approach to intervention studies and development of novel therapeutic approaches].

Authors:  T Ostendorf; J Floege
Journal:  Med Klin (Munich)       Date:  1999-04-15

8.  Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal.

Authors:  R Singh; H Banerjee; M R Green
Journal:  RNA       Date:  2000-06       Impact factor: 4.942

9.  The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.

Authors:  K B Jensen; K Musunuru; H A Lewis; S K Burley; R B Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

10.  Cytoplasmic RNA modulators of an inside-out signal-transduction cascade.

Authors:  M Blind; W Kolanus; M Famulok
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205
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