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Literature DB >> 7525989

Proteolytic processing of reovirus is required for adherence to intestinal M cells.

H M Amerongen¹, G A Wilson, B N Fields, M R Neutra.

Abstract

Reovirus adheres specifically to apical membranes of mouse intestinal M cells and exploits M-cell transepithelial transport activity to enter Peyer's patch mucosa, where replication occurs. Proteolytic conversion of native reovirus to intermediate subviral particles (ISVPs) occurs in the intestine, but it is not known whether conversion is essential for interaction of virus with M cells. We tested the capacity of native virions, ISVPs, and cores (that lack outer capsid proteins) to bind to intestinal epithelial cells in vivo and found that only ISVPs adhered to M cells. Thus, intraluminal conversion of native reovirus to ISVPs is a prerequisite for M-cell adherence, and outer capsid proteins unique to ISVPs (either sigma 1 or products of mu 1) mediate interaction of virus with M-cell apical membranes.

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Year: 1994 PMID： 7525989 PMCID： PMC237317

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

22 in total

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Authors: R L Owen; T H Ermak
Journal: Springer Semin Immunopathol Date: 1990

2. Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS.

Authors: H M Amerongen; R Weltzin; C M Farnet; P Michetti; W A Haseltine; M R Neutra
Journal: J Acquir Immune Defic Syndr (1988) Date: 1991

3. Intraluminal proteolytic activation plays an important role in replication of type 1 reovirus in the intestines of neonatal mice.

Authors: D M Bass; D Bodkin; R Dambrauskas; J S Trier; B N Fields; J L Wolf
Journal: J Virol Date: 1990-04 Impact factor: 5.103

4. Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1.

Authors: M L Nibert; T S Dermody; B N Fields
Journal: J Virol Date: 1990-06 Impact factor: 5.103

5. Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles.

Authors: D B Furlong; M L Nibert; B N Fields
Journal: J Virol Date: 1988-01 Impact factor: 5.103

6. Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction.

Authors: K A Dryden; G Wang; M Yeager; M L Nibert; K M Coombs; D B Furlong; B N Fields; T S Baker
Journal: J Cell Biol Date: 1993-09 Impact factor: 10.539

7. Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice.

Authors: D K Bodkin; M L Nibert; B N Fields
Journal: J Virol Date: 1989-11 Impact factor: 5.103

8. Poliovirus type 1 enters the human host through intestinal M cells.

Authors: P Siciński; J Rowiński; J B Warchoł; Z Jarzabek; W Gut; B Szczygieł; K Bielecki; G Koch
Journal: Gastroenterology Date: 1990-01 Impact factor: 22.682

9. A carboxy-terminal fragment of protein mu 1/mu 1C is present in infectious subvirion particles of mammalian reoviruses and is proposed to have a role in penetration.

Authors: M L Nibert; B N Fields
Journal: J Virol Date: 1992-11 Impact factor: 5.103

10. Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins.

Authors: R Weltzin; P Lucia-Jandris; P Michetti; B N Fields; J P Kraehenbuhl; M R Neutra
Journal: J Cell Biol Date: 1989-05 Impact factor: 10.539

50 in total

1. Infection of polarized cultures of human intestinal epithelial cells with hepatitis A virus: vectorial release of progeny virions through apical cellular membranes.

Authors: C A Blank; D A Anderson; M Beard; S M Lemon
Journal: J Virol Date: 2000-07 Impact factor: 5.103

2. Thermostability of reovirus disassembly intermediates (ISVPs) correlates with genetic, biochemical, and thermodynamic properties of major surface protein mu1.

Authors: Jason K Middleton; Tonya F Severson; Kartik Chandran; Anne Lynn Gillian; John Yin; Max L Nibert
Journal: J Virol Date: 2002-02 Impact factor: 5.103

3. Sites and determinants of early cleavages in the proteolytic processing pathway of reovirus surface protein sigma3.

Authors: Judit Jané-Valbuena; Laura A Breun; Leslie A Schiff; Max L Nibert
Journal: J Virol Date: 2002-05 Impact factor: 5.103

4. A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1.

Authors: George T Mercier; Jacquelyn A Campbell; James D Chappell; Thilo Stehle; Terence S Dermody; Michael A Barry
Journal: Proc Natl Acad Sci U S A Date: 2004-04-12 Impact factor: 11.205

Review 9. The immunopathology of M cells.

Authors: I C Davis; R L Owen
Journal: Springer Semin Immunopathol Date: 1997

10. Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches.

Authors: K J Silvey; A B Hutchings; M Vajdy; M M Petzke; M R Neutra
Journal: J Virol Date: 2001-11 Impact factor: 5.103