Literature DB >> 1856788

Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS.

H M Amerongen1, R Weltzin, C M Farnet, P Michetti, W A Haseltine, M R Neutra.   

Abstract

This study was designed to determine whether human immunodeficiency virus type 1 (HIV-1) might enter the host by penetrating epithelial barriers through antigen-transporting M cells in lymphoid follicle-associated epithelia. Interaction of HIV-1 with epithelial cells was examined using mucosal explants from Peyer's patches of mice and rabbits. HIV-1 adhered to the luminal membranes of M cells of both species, and was endocytosed and delivered to intraepithelial spaces containing lymphocytes and macrophages. These observations suggest that M cells, which are numerous in the human rectal mucosa, may efficiently deliver HIV-1 to target cells in mucosal lymphoid tissue, and that such transport may contribute to sexual transmission of AIDS.

Entities:  

Mesh：

Year:  1991        PMID： 1856788

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr (1988)        ISSN： 0894-9255


  60 in total

Review 1.  Secretory IgA: arresting microbial pathogens at epithelial borders.

Authors:  Nicholas J Mantis; Stephen J Forbes
Journal:  Immunol Invest       Date:  2010       Impact factor: 3.657

2.  Timed appearance of lymphocytic choriomeningitis virus after gastric inoculation of mice.

Authors:  S K Rai; B K Micales; M S Wu; D S Cheung; T D Pugh; G E Lyons; M S Salvato
Journal:  Am J Pathol       Date:  1997-08       Impact factor: 4.307

3.  Importance of gastrointestinal ingestion and macromolecular antigens in the vein for oral tolerance induction.

Authors:  Ayako Wakabayashi; Yoshihiro Kumagai; Eiji Watari; Masumi Shimizu; Masanori Utsuyama; Katsuiku Hirokawa; Hidemi Takahashi
Journal:  Immunology       Date:  2006-06-23       Impact factor: 7.397

4.  Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system.

Authors:  Franck Lemiale; Wing-pui Kong; Levent M Akyürek; Xu Ling; Yue Huang; Bimal K Chakrabarti; Michael Eckhaus; Gary J Nabel
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

5.  Oral immunization with recombinant Mycobacterium bovis BCG simian immunodeficiency virus nef induces local and systemic cytotoxic T-lymphocyte responses in mice.

Authors:  M Lagranderie; A M Balazuc; B Gicquel; M Gheorghiu
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

6.  Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.

Authors:  S S Frankel; K Tenner-Racz; P Racz; B M Wenig; C H Hansen; D Heffner; A M Nelson; M Pope; R M Steinman
Journal:  Am J Pathol       Date:  1997-07       Impact factor: 4.307

Review 7.  The immunopathology of M cells.

Authors:  I C Davis; R L Owen
Journal:  Springer Semin Immunopathol       Date:  1997

Review 8.  Vaginal microbicides and the prevention of HIV transmission.

Authors:  Blayne Cutler; Jessica Justman
Journal:  Lancet Infect Dis       Date:  2008-11       Impact factor: 25.071

9.  The role of M cells of human nasopharyngeal lymphoid tissue in influenza virus sampling.

Authors:  Yoshinori Fujimura; Masaharu Takeda; Hidenori Ikai; Ken Haruma; Takeshi Akisada; Tamotsu Harada; Tatsuya Sakai; Masanobu Ohuchi
Journal:  Virchows Arch       Date:  2003-10-10       Impact factor: 4.064

10.  Excretion of human immunodeficiency virus type 1 through polarized epithelium by immunoglobulin A.

Authors:  Alison Wright; Michael E Lamm; Yung T Huang
Journal:  J Virol       Date:  2008-10-01       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.