Literature DB >> 7524288

Platelet activating factor potentiates rat paw oedema induced by different phlogogen agents.

A A Izzo1, N Mascolo, M V Di Urno, G Autore, G Di Carlo, F Capasso.   

Abstract

Carrageenin oedema is enhanced by the simultaneous injection in the rat paw of platelet activating factor (PAF). The enhancement of carrageenin oedema is observed throughout the time course of the experiments. This enhancement is also present when the oedema-producing agent is dextran, cellulose sulphate, histamine, 5-hydroxytryptamine, bradykinin or prostaglandin E2. Both verapamil and BN 52021 abolished the enhancement induced by PAF without modifying significantly carrageenin oedema. In essential fatty acid deficient (EFAD) rats depleted of kininogen and amines, carrageenin oedema is not modified by PAF. These findings suggest that PAF interacts with other inflammatory mediators regulating the formation of oedema induced by irritants injected locally.

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Year:  1994        PMID： 7524288     DOI： 10.1007/bf02001907

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  19 in total

1.  Intravascular aggregation and pulmonary sequestration of platelets during IgE-induced systemic anaphylaxis in the rabbit: abrogation of lethal anaphylactic shock by platelet depletion.

Authors:  R N Pinckard; M Halonen; J D Palmer; C Butler; J O Shaw; P M Henson
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

Review 2.  Perspectives in platelet-activating factor research.

Authors:  P Braquet; L Touqui; T Y Shen; B B Vargaftig
Journal:  Pharmacol Rev       Date:  1987-06       Impact factor: 25.468

3.  Distinct stimulatory effect of platelet-activating factor on prostaglandin I2 and thromboxane A2 biosynthesis by rat dental pulp.

Authors:  M Hirafuji; Y Ogura
Journal:  Eur J Pharmacol       Date:  1990-08-21       Impact factor: 4.432

4.  Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts.

Authors:  G J Fisher; H S Talwar; N S Ryder; J J Voorhees
Journal:  Biochem Biophys Res Commun       Date:  1989-09-29       Impact factor: 3.575

5.  Enhancement of carrageenin foot oedema by 1,10 -phenanthroline and evidence for the bradykinin as endogenous mediator.

Authors:  F Capasso; B Balestrieri; M Di Rosa; P Persico; L Sorrentino
Journal:  Agents Actions       Date:  1975-10

6.  Potent ulcerogenic actions of platelet-activating factor on the stomach.

Authors:  A C Rosam; J L Wallace; B J Whittle
Journal:  Nature       Date:  1986 Jan 2-8       Impact factor: 49.962

7.  Histamine release from human leukocytes by platelet-activating factor.

Authors:  Y Okuda; I Tsuyuguchi; A Yamatodani
Journal:  Int Arch Allergy Appl Immunol       Date:  1988

8.  Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.

Authors:  B B Vargaftig; S H Ferreira
Journal:  Braz J Med Biol Res       Date:  1981-07       Impact factor: 2.590

9.  The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall.

Authors:  R H Bourgain; L Maes; P Braquet; R Andries; L Touqui; M Braquet
Journal:  Prostaglandins       Date:  1985-08

10.  Platelet activating factor and the responses of rat isolated stomach strip to prostaglandin E2.

Authors:  A A Izzo; N Mascolo; G Autore; F Capasso
Journal:  J Pharm Pharmacol       Date:  1993-08       Impact factor: 3.765
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