Literature DB >> 6802210

Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.

B B Vargaftig, S H Ferreira.   

Abstract

1. The edematogenic and hyperalgesic effects of synthetic Platelet-Activating Factor (PAF-acether) on the rat paw were investigated. 2. PAF-acether induced a dose-dependent oedema and hyperalgesia. 3. These effects were partially reduced by non-steroidal anti-inflammatory agents. 4. It is suggested that the oedema and hyperalgesia in response to PAF-acether are due at least in part to the release of a cyclo-oxygenase metabolite, probably prostacyclin.

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Year:  1981        PMID： 6802210

Source DB:  PubMed          Journal:  Braz J Med Biol Res        ISSN： 0100-879X            Impact factor:   2.590


  13 in total

1.  Inhibition of Paf-acether-induced edema of the rat's paw.

Authors:  K F Swingle; M J Reiter
Journal:  Agents Actions       Date:  1986-06

2.  Failure of PAF-acether to induce in vivo neutrophil migration.

Authors:  F Q Cunha; N E Heluy-Neto; A Klein; G E Souza; S H Ferreira
Journal:  Agents Actions       Date:  1988-08

3.  The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.

Authors:  J Lefort; D Rotilio; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

4.  Effect of PAF on rat lung vascular permeability: role of platelets and polymorphonuclear leucocytes.

Authors:  M G Sirois; W T de Lima; A J de Brum Fernandes; R J Johnson; G E Plante; P Sirois
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

5.  Platelet involvement in rat paw edema induced by 2-methoxy-PAF.

Authors:  P M Silva; R S Cordeiro; M A Martins; M G Henriques; B B Vargaftig
Journal:  Inflammation       Date:  1986-12       Impact factor: 4.092

6.  Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung.

Authors:  J P Seale; S Nourshargh; P G Hellewell; T J Williams
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

7.  Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse.

Authors:  M G Henriques; V B Weg; M A Martins; P M Silva; P D Fernandes; R S Cordeiro; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

8.  Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether.

Authors:  A Detsouli; J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1985-04       Impact factor: 8.739

9.  Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin.

Authors:  J Morley; C P Page; W Paul
Journal:  Br J Pharmacol       Date:  1983-11       Impact factor: 8.739

10.  Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.

Authors:  M A Martins; P M Silva; H C Faria Neto; P T Bozza; P M Dias; M C Lima; R S Cordeiro; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739
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