Literature DB >> 75239

Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia.

D Meruelo, S H Nimelstein, P P Jones, M Lieberman, H O McDevitt.   

Abstract

Previous studies from this laboratory have mapped resistance and/or susceptibility to radiation-induced leukemia virus (RadLV)-induced neoplasia to the H-2D region. H-2 linked effects on virus replication can be detected subsequent to the initial virus infection, and clear-cut differences in numbers of virus infected thymus cells can be detected as early as 5 wk after RadLV inoculation. Rapid increases in cellular synthesis and cell surface expression of H-2 antigens are detectable immediately after virus inoculation. These changes have been studied by immunofluorescence, absorption, cell surface iodination followed by sodium dodecyl-sulfate-polyacrylamide gel electrophoresis, and two dimensional gel electrophoretic analysis of internally labeled lymphocyte proteins. Expression of H-2K molecules is significantly increased in cells of susceptible and resistant animals. However, significant increases in expression of H-2D antigens occurs only on thymus cells from resistant strains (H-2Dd). Transformed cells of resistant and susceptible H-2 haplotypes adapted to tissue culture lack detectable H-2 antigens as determined by serological absorption studies. It is argued that altered expression of H-2 antigens plays a very significant role in the mechanism of host defense to virus infection.

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Year:  1978        PMID: 75239      PMCID: PMC2184498          DOI: 10.1084/jem.147.2.470

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  28 in total

1.  Fluorescence-activated cell sorting.

Authors:  L A Herzenberg; R G Sweet; L A Herzenberg
Journal:  Sci Am       Date:  1976-03       Impact factor: 2.142

Review 2.  Leukemia and lymphoma in experimental and domestic animals.

Authors:  H S Kaplan
Journal:  Ser Haematol       Date:  1974

3.  Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin.

Authors:  D Roos; J A Loos
Journal:  Biochim Biophys Acta       Date:  1970-12-29

4.  Absence of H-2 antigens capable of reacting with cytotoxic T cells on a teratoma line expressing a T/t locus antigen.

Authors:  J Forman; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

5.  The importance of serologically detectable histocompatibility antigens in the induction and effector step of cell-mediated lysis.

Authors:  G Dennert; R Hyman
Journal:  Eur J Immunol       Date:  1977-05       Impact factor: 5.532

6.  Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.

Authors:  B Chesebro; K Wehrly
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

7.  Studies on the role of the host immune response in recovery from Friend virus leukemia. I. Antiviral and antileukemia cell antibodies.

Authors:  B Chesebro; K Wehrly
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

8.  Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.

Authors:  B Chesebro; K Wehrly; J Stimpfling
Journal:  J Exp Med       Date:  1974-12-01       Impact factor: 14.307

9.  Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

Authors:  P P Jones
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

10.  The effect of histocompatibility-2 type on response to friend leukemia virus in mice.

Authors:  F Lilly
Journal:  J Exp Med       Date:  1968-03-01       Impact factor: 14.307

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  23 in total

1.  Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

Authors:  D Meruelo; R Kornreich; A Rossomando; C Pampeno; A Boral; J L Silver; J Buxbaum; E H Weiss; J J Devlin; A L Mellor
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

2.  A transcriptional enhancer and an interferon-responsive sequence in major histocompatibility complex class I genes.

Authors:  J Vogel; M Kress; G Khoury; G Jay
Journal:  Mol Cell Biol       Date:  1986-10       Impact factor: 4.272

3.  Murine retroviruses control class I major histocompatibility antigen gene expression via a trans effect at the transcriptional level.

Authors:  L D Wilson; D C Flyer; D V Faller
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

4.  Evidence for H-2-linked control of retrovirus production in Friend virus-induced tumor cell lines.

Authors:  J H Wolfe; K J Blank
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

5.  H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance.

Authors:  S E Bear; P N Tsichlis; R S Schwartz
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

6.  A transcript from the long terminal repeats of a murine retrovirus associated with trans activation of cellular genes.

Authors:  S Y Choi; D V Faller
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

Review 7.  Role of the major histocompatibility complex in resistance to viral leukemia; its effect on the preleukemic stage of leukemogenesis.

Authors:  P Lonai; E Katz; N Haran-Ghera
Journal:  Springer Semin Immunopathol       Date:  1982

8.  Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A.

Authors:  D Meruelo; M Offer; A Rossomando
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

9.  Murine leukemia virus sequences are encoded in the murine major histocompatibility complex.

Authors:  D Meruelo; R Kornreich; A Rossomando; C Pampeno; A L Mellor; E H Weiss; R A Flavell; A Pellicer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K.

Authors:  W Schmidt; L Leben; G Atfield; H Festenstein
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

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