| Literature DB >> 6101117 |
S E Bear1, P N Tsichlis, R S Schwartz.
Abstract
H-2 recombinant mice of the C57BL/10 series were used to study resistance to infection by an ecotropic (B-tropic) type C retrovirus. The gene(s) responsible for resistance was mapped to I-E/I-C subregions. Ontogenic studies indicated that this I-region mediated resistance is not present in the neonate but develops with age, and is firmly established within 2 weeks after birth. This temporary neonatal susceptibility in mice of resistant genotype is not the result of active suppression of the immune response.Entities:
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Year: 1980 PMID: 6101117 DOI: 10.1007/bf01567814
Source DB: PubMed Journal: Immunogenetics ISSN: 0093-7711 Impact factor: 2.846