Literature DB >> 7523701

Poor transduction efficiency of human hematopoietic progenitor cells by a high-titer amphotropic retrovirus producer cell clone.

L C Xu1, H A Young, M Blanco, S Kessler, A B Roberts, S Karlsson.   

Abstract

The transduction efficiency of human bone marrow CD34+ cells with supernatants from the retrovirus producer cell clone PA317/LGSN 16 was only one-fifth of that with supernatants from GP+ envAm12/LGSN 15, even though both producers had similar infection titers on 3T3 cells. PA317/LGSN 16-conditioned medium inhibited the proliferation of the bone marrow CD34+ cells, and this inhibitory effect was partially blocked by anti-transforming growth factor beta antibodies. These studies suggest that cytokine secretion plays a role in the suppression of retrovirus transduction of human CD34+ cells.

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Year:  1994        PMID： 7523701      PMCID： PMC237215     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

Review 1.  Human gene therapy.

Authors:  W F Anderson
Journal:  Science       Date:  1992-05-08       Impact factor: 47.728

2.  Construction and use of a safe and efficient amphotropic packaging cell line.

Authors:  D Markowitz; S Goff; A Bank
Journal:  Virology       Date:  1988-12       Impact factor: 3.616

3.  Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow.

Authors:  T M Folks; S W Kessler; J M Orenstein; J S Justement; E S Jaffe; A S Fauci
Journal:  Science       Date:  1988-11-11       Impact factor: 47.728

4.  Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro.

Authors:  G K Sing; J R Keller; L R Ellingsworth; F W Ruscetti
Journal:  Blood       Date:  1988-11       Impact factor: 22.113

5.  Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture.

Authors:  D Danielpour; L L Dart; K C Flanders; A B Roberts; M B Sporn
Journal:  J Cell Physiol       Date:  1989-01       Impact factor: 6.384

6.  Expression and secretion of type beta transforming growth factor by activated human macrophages.

Authors:  R K Assoian; B E Fleurdelys; H C Stevenson; P J Miller; D K Madtes; E W Raines; R Ross; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

Review 7.  Retrovirus packaging cells.

Authors:  A D Miller
Journal:  Hum Gene Ther       Date:  1990       Impact factor: 5.695

8.  Correction of the enzyme deficiency in hematopoietic cells of Gaucher patients using a clinically acceptable retroviral supernatant transduction protocol.

Authors:  L Xu; S K Stahl; H P Dave; R Schiffmann; P H Correll; S Kessler; S Karlsson
Journal:  Exp Hematol       Date:  1994-02       Impact factor: 3.084

9.  A safe packaging line for gene transfer: separating viral genes on two different plasmids.

Authors:  D Markowitz; S Goff; A Bank
Journal:  J Virol       Date:  1988-04       Impact factor: 5.103

10.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors:  J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
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