Literature DB >> 7523148

Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction.

N E Tsopanoglou1, E Pipili-Synetos, M E Maragoudakis.   

Abstract

The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent and selective peptidyl leukotriene receptor antagonist, SK&F 104353-Z2, abolished the angiogenic effects of leukotrienes C4 and D4 and reduced unstimulated angiogenesis. These results indicate that leukotrienes C4 and D4 promote angiogenesis in the chick chorioallantoic membrane via a receptor-mediated interaction.

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Year:  1994        PMID： 7523148     DOI： 10.1016/0014-2999(94)90068-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

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Review 10.  Leukotrienes in Tumor-Associated Inflammation.

Authors:  Wen Tian; Xinguo Jiang; Dongeon Kim; Torrey Guan; Mark R Nicolls; Stanley G Rockson
Journal:  Front Pharmacol       Date:  2020-08-19       Impact factor: 5.810
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