Literature DB >> 7518303

Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.

J Longmore1, Z Razzaque, D Shaw, R G Hill.   

Abstract

1. The effects of the NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on NK1-agonist evoked contractions were compared in isolated rings of guinea-pig tracheal smooth muscle. 2. (+/-)-CP 96,345 and CP 99,994 were similarly effective in antagonizing responses evoked by septide, whereas CP 99,994 was more effective than (+/-)-CP 96,345 in inhibiting responses evoked by [Sar9Met11(O2)] substance P. 3. These results suggest that responses to septide and [Sar9Met11(O2)] substance P may be operated via different populations of NK1-receptors.

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Year:  1994        PMID： 7518303      PMCID： PMC1910287          DOI： 10.1111/j.1476-5381.1994.tb13048.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

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Authors:  S J Ireland; F Bailey; A Cook; R M Hagan; C C Jordan; M L Stephens-Smith
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  2 in total

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  2 in total

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