Literature DB >> 7511815

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

S Klages1, D Adam, K Class, J Fargnoli, J B Bolen, R C Penhallow.   

Abstract

We used the polymerase chain reaction with degenerate oligonucleotide primers to search for Csk-related kinases. A cDNA coding for a Csk-like protein-tyrosine kinase was cloned from mouse brain and was designated ctk, for csk-type protein-tyrosine kinase. The 1.9-kb ctk mRNA was found to be expressed predominantly in brain and capable of encoding a 52-kDa protein-tyrosine kinase. The amino acid sequence of Ctk was found to possess 53% identity with mouse Csk, shared all the predicted structural features of Csk, and was capable of phosphorylating the carboxyl-terminal conserved tyrosine of Src family members. Our results thereby indicate that ctk represents a gene that defines a family of structurally and functionally related Csk-like protein-tyrosine kinases.

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Year:  1994        PMID： 7511815      PMCID： PMC43416          DOI： 10.1073/pnas.91.7.2597

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

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Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

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Authors:  A Veillette; M A Bookman; E M Horak; J B Bolen
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Journal:  Cell       Date:  1993-06-18       Impact factor: 41.582

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  20 in total

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6.  Molecular cloning of a protein kinase whose phosphorylation is regulated by genetic adhesion during Chlamydomonas fertilization.

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Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

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