Literature DB >> 7510587

Status epilepticus results in reversible neuronal injury in infant rat hippocampus: novel use of a marker.

D Chang1, T Z Baram.   

Abstract

Despite ready induction of severe limbic status epilepticus by systemic kainic acid (KA) in infant rats, excitotoxic neuronal injury has not been observed. The mechanisms of this resistance of the immature hippocampus to excitotoxicity are unknown. Acid fuchsin stain has been used as a marker of irreversibly injured neurons in the adult brain. We speculated that the dye might map reversibly injured neurons in the infant. Subsequent to KA-induced status epilepticus in 11-day-old rats, acid fuchsin stain was evident in the hippocampal CA3, CA1, dentate gyrus and hilus by 24 h, peaked at 48 h and disappeared by 6 days, without evidence for neuronal loss. Acid fuchsin may be a useful tool for delineating the distribution of reversibly injured immature neurons in experimental seizure paradigms.

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Year:  1994        PMID： 7510587      PMCID： PMC3789625          DOI： 10.1016/0165-3806(94)90220-8

Source DB:  PubMed          Journal:  Brain Res Dev Brain Res        ISSN： 0165-3806


  18 in total

Review 1.  Developmental differences in the neurobiology of epileptic brain damage.

Authors:  E F Sperber; P K Stanton; K Haas; R F Ackermann; S L Moshé
Journal:  Epilepsy Res Suppl       Date:  1992

2.  Distribution of HSP72 induction and neuronal death following limbic seizures.

Authors:  S Shimosaka; Y T So; R P Simon
Journal:  Neurosci Lett       Date:  1992-04-27       Impact factor: 3.046

3.  Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

Authors:  T Z Baram; E Hirsch; O C Snead; L Schultz
Journal:  Ann Neurol       Date:  1992-05       Impact factor: 10.422

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Authors:  T Sutula; X X He; J Cavazos; G Scott
Journal:  Science       Date:  1988-03-04       Impact factor: 47.728

Review 5.  Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy.

Authors:  J V Nadler
Journal:  Life Sci       Date:  1981-11-16       Impact factor: 5.037

6.  Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates.

Authors:  E W Lothman; R C Collins
Journal:  Brain Res       Date:  1981-08-10       Impact factor: 3.252

7.  Resistance of the immature hippocampus to seizure-induced synaptic reorganization.

Authors:  E F Sperber; K Z Haas; P K Stanton; S L Moshé
Journal:  Brain Res Dev Brain Res       Date:  1991-05-20

8.  Continuous c-fos expression precedes programmed cell death in vivo.

Authors:  R J Smeyne; M Vendrell; M Hayward; S J Baker; G G Miao; K Schilling; L M Robertson; T Curran; J I Morgan
Journal:  Nature       Date:  1993-05-13       Impact factor: 49.962

9.  Kainic acid-induced limbic seizures: electrophysiologic studies.

Authors:  E W Lothman; R C Collins; J A Ferrendelli
Journal:  Neurology       Date:  1981-07       Impact factor: 9.910

10.  Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing.

Authors:  D M Labiner; L S Butler; Z Cao; D A Hosford; C Shin; J O McNamara
Journal:  J Neurosci       Date:  1993-02       Impact factor: 6.167
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  11 in total

Review 1.  Lessons from the laboratory: the pathophysiology, and consequences of status epilepticus.

Authors:  Karthik Rajasekaran; Santina A Zanelli; Howard P Goodkin
Journal:  Semin Pediatr Neurol       Date:  2010-09       Impact factor: 1.636

2.  Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats.

Authors:  C E Ribak; T Z Baram
Journal:  Brain Res Dev Brain Res       Date:  1996-02-26

3.  Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model.

Authors:  Z Toth; X X Yan; S Haftoglou; C E Ribak; T Z Baram
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

4.  Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.

Authors:  H Kubová; R Druga; K Lukasiuk; L Suchomelová; R Haugvicová; I Jirmanová; A Pitkänen
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

5.  Peptide-induced infant status epilepticus causes neuronal death and synaptic reorganization.

Authors:  T Z Baram; C E Ribak
Journal:  Neuroreport       Date:  1995-01-26       Impact factor: 1.837

6.  Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.

Authors:  Mark Dunleavy; Sachiko Shinoda; Clara Schindler; Claire Ewart; Ross Dolan; Oliviero L Gobbo; Christian M Kerskens; David C Henshall
Journal:  Am J Pathol       Date:  2009-11-30       Impact factor: 4.307

Review 7.  Is neuronal death required for seizure-induced epileptogenesis in the immature brain?

Authors:  Tallie Z Baram; Mariam Eghbal-Ahmadi; Roland A Bender
Journal:  Prog Brain Res       Date:  2002       Impact factor: 2.453

8.  The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation.

Authors:  K L Brunson; L Schultz; T Z Baram
Journal:  Brain Res Dev Brain Res       Date:  1998-11-01

9.  Patterns of status epilepticus-induced neuronal injury during development and long-term consequences.

Authors:  R Sankar; D H Shin; H Liu; A Mazarati; A Pereira de Vasconcelos; C G Wasterlain
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

10.  Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.

Authors:  J Motte; M J Fernandes; T Z Baram; A Nehlig
Journal:  Brain Res       Date:  1998-05-18       Impact factor: 3.252
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