Literature DB >> 7508762

The pore dimensions of gramicidin A.

O S Smart1, J M Goodfellow, B A Wallace.   

Abstract

The ion channel forming peptide gramicidin A adopts a number of distinct conformations in different environments. We have developed a new method to analyze and display the pore dimensions of ion channels. The procedure is applied to two x-ray crystal structures of gramicidin that adopt distinct antiparallel double helical dimer conformations and a nuclear magnetic resonance (NMR) structure for the beta6.3 NH2-terminal to NH2-terminal dimer. The results are discussed with reference to ion conductance properties and dependence of pore dimensions on the environment.

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Year:  1993        PMID： 7508762      PMCID： PMC1225986          DOI： 10.1016/S0006-3495(93)81293-1

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  31 in total

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Authors:  D G Levitt; L J Banaszak
Journal:  J Mol Graph       Date:  1992-12

2.  X-ray analysis and protein structure.

Authors:  D C HODGKIN
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1950

3.  Molecular dynamics computations and solid state nuclear magnetic resonance of the gramicidin cation channel.

Authors:  S W Chiu; L K Nicholson; M T Brenneman; S Subramaniam; Q Teng; J A McCammon; T A Cross; E Jakobsson
Journal:  Biophys J       Date:  1991-10       Impact factor: 4.033

4.  Ion-bond forms of the gramicidin a transmembrane channel.

Authors:  B A Wallace
Journal:  Biophys J       Date:  1984-01       Impact factor: 4.033

5.  Effect of linear gramicidin on sporulation and intracellular ATP pools of Bacillus brevis.

Authors:  J Mandl; H Paulus
Journal:  Arch Microbiol       Date:  1985-12       Impact factor: 2.552

6.  Three-dimensional structure at 0.86 A of the uncomplexed form of the transmembrane ion channel peptide gramicidin A.

Authors:  D A Langs
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

7.  Conformation of peptide chains containing both L- & D-residues. I. Helical structures with alternating L- & D-residues with special reference to the LD-ribbon & the LD-helices.

Authors:  G N Ramachnandran; R Chandrasekaran
Journal:  Indian J Biochem Biophys       Date:  1972-03       Impact factor: 1.918

8.  Conformation of the gramicidin A transmembrane channel: A 13C nuclear magnetic resonance study of 13C-enriched gramicidin in phosphatidylcholine vesicles.

Authors:  S Weinstein; B A Wallace; J S Morrow; W R Veatch
Journal:  J Mol Biol       Date:  1980-10-15       Impact factor: 5.469

9.  Solvent-accessible surfaces of proteins and nucleic acids.

Authors:  M L Connolly
Journal:  Science       Date:  1983-08-19       Impact factor: 47.728

10.  DNA-supercoiling is affected in vitro by the peptide antibiotics tyrocidine and gramicidin.

Authors:  A Bohg; H Ristow
Journal:  Eur J Biochem       Date:  1986-11-03
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  264 in total

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Journal:  Biophys J       Date:  1999-07       Impact factor: 4.033

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Authors:  J Gullingsrud; D Kosztin; K Schulten
Journal:  Biophys J       Date:  2001-05       Impact factor: 4.033

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Authors:  V Borisenko; M S Sansom; G A Woolley
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Authors:  D P Tieleman; H J Berendsen; M S Sansom
Journal:  Biophys J       Date:  1999-04       Impact factor: 4.033

6.  Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy.

Authors:  S J Opella; F M Marassi; J J Gesell; A P Valente; Y Kim; M Oblatt-Montal; M Montal
Journal:  Nat Struct Biol       Date:  1999-04

7.  Hierarchical approach to predicting permeation in ion channels.

Authors:  R J Mashl; Y Tang; J Schnitzer; E Jakobsson
Journal:  Biophys J       Date:  2001-11       Impact factor: 4.033

8.  Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.

Authors:  Charlotte E Capener; Peter Proks; Frances M Ashcroft; Mark S P Sansom
Journal:  Biophys J       Date:  2003-04       Impact factor: 4.033

9.  Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer.

Authors:  I H Shrivastava; M S Sansom
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

10.  Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor.

Authors:  Alexander C Saladino; Yan Xu; Pei Tang
Journal:  Biophys J       Date:  2004-12-01       Impact factor: 4.033
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