Literature DB >> 7506516

Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers.

M Virkkunen1, E Kallio, R Rawlings, R Tokola, R E Poland, A Guidotti, C Nemeroff, G Bissette, K Kalogeras, S L Karonen.   

Abstract

BACKGROUND: Based on clinical observations in a series of studies on Finnish alcoholic, violent offenders, we asserted that the impulsive offenders represented an extreme group of type 2 alcoholics. We also observed that these subjects were vulnerable to hypoglycemia after the administration of oral glucose load. Furthermore, we believe that while being hypoglycemic, the impulsive offenders are particularly irritable and aggressive. In the present study, we addressed these issues by studying psychological trait and state variables in a new group of violent offenders and fire setters, and age- and sex-matched healthy volunteers.
METHODS: Fifty-eight alcoholic, violent offenders and impulsive fire setters and 21 healthy volunteers were administered the Karolinska scales of personality and the Rosenzweig picture frustration test after an oral aspartame and glucose challenge.
RESULTS: The psychological test results and the criminal histories of the offenders, together with biochemical measurements, suggest that a low 5-hydroxyindoleacetic acid concentration in cerebrospinal fluid in the alcoholic offenders is associated with irritability and impaired impulse control, and a high free testosterone concentration in cerebrospinal fluid is associated with increased aggressiveness, monotony avoidance, sensation seeking, suspiciousness, and reduced socialization.
CONCLUSION: Finnish alcoholic, impulsive offenders have personality profiles characteristic of Scandinavian early-onset male alcoholics with antisocial traits, who have been also referred to as type 2 alcoholics.

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Year:  1994        PMID: 7506516     DOI: 10.1001/archpsyc.1994.03950010028004

Source DB:  PubMed          Journal:  Arch Gen Psychiatry        ISSN: 0003-990X


  15 in total

Review 1.  Cognitive and neurobiological mechanisms of alcohol-related aggression.

Authors:  Adrienne J Heinz; Anne Beck; Andreas Meyer-Lindenberg; Philipp Sterzer; Andreas Heinz
Journal:  Nat Rev Neurosci       Date:  2011-06-02       Impact factor: 34.870

2.  Neurodevelopmental liabilities of substance abuse.

Authors:  Tomas Palomo; Trevor Archer; Richard J Beninger; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2002-06       Impact factor: 3.911

3.  Dual origins of Finns revealed by Y chromosome haplotype variation.

Authors:  R A Kittles; M Perola; L Peltonen; A W Bergen; R A Aragon; M Virkkunen; M Linnoila; D Goldman; J C Long
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

4.  Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits.

Authors:  R A Kittles; J C Long; A W Bergen; M Eggert; M Virkkunen; M Linnoila; D Goldman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

Review 5.  Neurobiology of sociability.

Authors:  Heather K Caldwell
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

6.  Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI.

Authors:  Katya Rubia; Francis Lee; Anthony J Cleare; Nigel Tunstall; Cynthia H Y Fu; Michael Brammer; Phillip McGuire
Journal:  Psychopharmacology (Berl)       Date:  2005-01-26       Impact factor: 4.530

7.  Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.

Authors:  L Clark; J P Roiser; R Cools; D C Rubinsztein; B J Sahakian; T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  2005-10-19       Impact factor: 4.530

Review 8.  Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence.

Authors:  M Virkkunen; D Goldman; D A Nielsen; M Linnoila
Journal:  J Psychiatry Neurosci       Date:  1995-07       Impact factor: 6.186

Review 9.  Alcohol and violence: neuropeptidergic modulation of monoamine systems.

Authors:  Klaus A Miczek; Joseph F DeBold; Lara S Hwa; Emily L Newman; Rosa M M de Almeida
Journal:  Ann N Y Acad Sci       Date:  2015-08-18       Impact factor: 5.691

10.  Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study.

Authors:  Linda Booij; Richard E Tremblay; Marco Leyton; Jean R Séguin; Frank Vitaro; Paul Gravel; Elisabeth Perreau-Linck; Mélissa L Lévesque; France Durand; Mirko Diksic; Gustavo Turecki; Chawki Benkelfat
Journal:  PLoS One       Date:  2010-06-22       Impact factor: 3.240

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