Literature DB >> 7504264

Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.

A V Moses1, F E Bloom, C D Pauza, J A Nelson.   

Abstract

Neuropathologic studies of AIDS patients have shown that brain capillary endothelial cells are a cellular target for human immunodeficiency virus (HIV) in vivo. We have established in vitro cultures of primary human brain capillary endothelial (HBCE) cells. Using this model system, we have shown a significant HIV infection of HBCE cells that is productive yet noncytopathic. The infection is mediated by a cellular interaction with gp120 that does not involve CD4 or galactosylceramide. HIV infection of HBCE cells may contribute to AIDS-associated neuropathology by disturbing the physiology of the endothelium and directly or indirectly facilitating dissemination of virus to the central nervous system.

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Year:  1993        PMID： 7504264      PMCID： PMC47799          DOI： 10.1073/pnas.90.22.10474

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  46 in total

1.  Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells.

Authors:  P R Clapham; J N Weber; D Whitby; K McIntosh; A G Dalgleish; P J Maddon; K C Deen; R W Sweet; R A Weiss
Journal:  Nature       Date:  1989-01-26       Impact factor: 49.962

2.  Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide.

Authors:  D E Brenneman; G L Westbrook; S P Fitzgerald; D L Ennist; K L Elkins; M R Ruff; C B Pert
Journal:  Nature       Date:  1988-10-13       Impact factor: 49.962

3.  Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections.

Authors:  J M Ward; T J O'Leary; G B Baskin; R Benveniste; C A Harris; P L Nara; R H Rhodes
Journal:  Am J Pathol       Date:  1987-05       Impact factor: 4.307

4.  Human immunodeficiency virus can productively infect cultured human glial cells.

Authors:  C Cheng-Mayer; J T Rutka; M L Rosenblum; T McHugh; D P Stites; J A Levy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

5.  AIDS subacute encephalitis. Identification of HIV-infected cells.

Authors:  R Vazeux; N Brousse; A Jarry; D Henin; C Marche; C Vedrenne; J Mikol; M Wolff; C Michon; W Rozenbaum
Journal:  Am J Pathol       Date:  1987-03       Impact factor: 4.307

Review 6.  The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.

Authors:  R W Price; B Brew; J Sidtis; M Rosenblum; A C Scheck; P Cleary
Journal:  Science       Date:  1988-02-05       Impact factor: 47.728

7.  HIV antigen in the brains of patients with the AIDS dementia complex.

Authors:  T Pumarola-Sune; B A Navia; C Cordon-Cardo; E S Cho; R W Price
Journal:  Ann Neurol       Date:  1987-05       Impact factor: 10.422

Review 8.  Vascular endothelium in immunology and infectious disease.

Authors:  M A Beilke
Journal:  Rev Infect Dis       Date:  1989 Mar-Apr

9.  Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope.

Authors:  S Matsushita; M Robert-Guroff; J Rusche; A Koito; T Hattori; H Hoshino; K Javaherian; K Takatsuki; S Putney
Journal:  J Virol       Date:  1988-06       Impact factor: 5.103

10.  Human immunodeficiency virus in brain biopsies of patients with AIDS and progressive encephalopathy.

Authors:  F Gyorkey; J L Melnick; P Gyorkey
Journal:  J Infect Dis       Date:  1987-05       Impact factor: 5.226
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  66 in total

Review 1.  In vitro and animal models of human immunodeficiency virus infection of the central nervous system.

Authors:  Chadd E Nesbit; Stanley A Schwartz
Journal:  Clin Diagn Lab Immunol       Date:  2002-05

2.  Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway.

Authors:  Nancy Q Liu; Albert S Lossinsky; Waldemar Popik; Xia Li; Chandrasekhar Gujuluva; Benjamin Kriederman; Jaclyn Roberts; Tatania Pushkarsky; Michael Bukrinsky; Marlys Witte; Martin Weinand; Milan Fiala
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

3.  Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.

Authors:  S Mitola; R Soldi; I Zanon; L Barra; M I Gutierrez; B Berkhout; M Giacca; F Bussolino
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

4.  Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.

Authors:  L M Dallasta; L A Pisarov; J E Esplen; J V Werley; A V Moses; J A Nelson; C L Achim
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

Review 5.  In vitro methods in the study of viral and prion permeability across the blood-brain barrier.

Authors:  Ryota Nakaoke; William A Banks
Journal:  Cell Mol Neurobiol       Date:  2005-02       Impact factor: 5.046

6.  Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A.

Authors:  Moti L Chapagain; Saguna Verma; Frederic Mercier; Richard Yanagihara; Vivek R Nerurkar
Journal:  Virology       Date:  2007-03-30       Impact factor: 3.616

7.  Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.

Authors:  V G Sasseville; M M Smith; C R Mackay; D R Pauley; K G Mansfield; D J Ringler; A A Lackner
Journal:  Am J Pathol       Date:  1996-11       Impact factor: 4.307

8.  Persistent SIV infection of a blood-brain barrier model.

Authors:  Lisa Strelow; Damir Janigro; Jay A Nelson
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643

9.  Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro.

Authors:  J L Mankowski; J P Spelman; H G Ressetar; J D Strandberg; J Laterra; D L Carter; J E Clements; M C Zink
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

10.  Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences.

Authors:  C Power; J C McArthur; R T Johnson; D E Griffin; J D Glass; S Perryman; B Chesebro
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103
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