Literature DB >> 17399760

Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A.

Moti L Chapagain1, Saguna Verma, Frederic Mercier, Richard Yanagihara, Vivek R Nerurkar.   

Abstract

Although human polyomavirus JC (JCV) is known to cause progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals, the mechanism by which JCV crosses the blood-brain barrier (BBB) remains unclear. To test our hypothesis that cell-free JCV gains entry into the brain by infecting endothelial cells, we inoculated human brain microvascular endothelial (HBMVE) cells with 50 HAU (1.33+/-0.27 x 10(7) genome copies) of JCV(Mad1) and analyzed the expression of early and late viral genes and proteins by immunocytochemistry, quantitative real-time PCR (qPCR), quantitative real-time reverse transcriptase PCR (qRT-PCR) and immunoprecipitation followed by Western blotting. JCV infected and replicated efficiently in HBMVE cells and produced infectious virions several hundred fold higher than the infecting inoculum. HBMVE cells in vitro did not express serotonin receptor 2A (5HT(2A)R), and 5HT(2A)R blockers did not prevent JCV infection of HBMVE cells. Collectively, our data indicate that the productive in vitro infection of HBMVE cells by JCV is independent of 5HT(2A)R.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17399760      PMCID： PMC2034208          DOI： 10.1016/j.virol.2007.02.018

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  36 in total

1.  Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway.

Authors:  Nancy Q Liu; Albert S Lossinsky; Waldemar Popik; Xia Li; Chandrasekhar Gujuluva; Benjamin Kriederman; Jaclyn Roberts; Tatania Pushkarsky; Michael Bukrinsky; Marlys Witte; Martin Weinand; Milan Fiala
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

2.  Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS.

Authors:  Sarah M Richardson-Burns; B K Kleinschmidt-DeMasters; Roberta L DeBiasi; Kenneth L Tyler
Journal:  Arch Neurol       Date:  2002-12

3.  Early events in the life cycle of JC virus as potential therapeutic targets for the treatment of progressive multifocal leukoencephalopathy.

Authors:  S Baum; A Ashok; G Gee; S Dimitrova; W Querbes; J Jordan; Walter J Atwood
Journal:  J Neurovirol       Date:  2003       Impact factor: 2.643

4.  Reconstructing population history using JC virus: Amerinds, Spanish, and Africans in the ancestry of modern Puerto Ricans.

Authors:  M Fernandez-Cobo; D V Jobes; R Yanagihara; V R Nerurkar; Y Yamamura; C F Ryschkewitsch; G L Stoner
Journal:  Hum Biol       Date:  2001-06       Impact factor: 0.553

5.  JC virus genotypes in France: molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy.

Authors:  V Dubois; H Moret; M E Lafon; V Brodard; J Icart; A Ruffault; O Guist'hau; C Buffet-Janvresse; K Abbed; E Dussaix; D Ingrand
Journal:  J Infect Dis       Date:  2000-11-29       Impact factor: 5.226

6.  Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40.

Authors:  Wendy A Knowles; Pam Pipkin; Nick Andrews; Andrew Vyse; Philip Minor; David W G Brown; Elizabeth Miller
Journal:  J Med Virol       Date:  2003-09       Impact factor: 2.327

7.  CD46- and CD150-independent endothelial cell infection with wild-type measles viruses.

Authors:  Oliver Andres; Karola Obojes; Kwang Sik Kim; Volker Ter Meulen; Jürgen Schneider-Schaulies
Journal:  J Gen Virol       Date:  2003-05       Impact factor: 3.891

8.  Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN.

Authors:  Muhammad Mukhtar; Steve Harley; Peiqin Chen; Mohammed BouHamdan; Charvi Patel; Edward Acheampong; Roger J Pomerantz
Journal:  Virology       Date:  2002-05-25       Impact factor: 3.616

9.  Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts.

Authors:  Elias G Argyris; Edward Acheampong; Giuseppe Nunnari; Muhammad Mukhtar; Kevin Jon Williams; Roger J Pomerantz
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  New JC virus infection patterns by in situ polymerase chain reaction in brains of acquired immunodeficiency syndrome patients with progressive multifocal leukoencephalopathy.

Authors:  Regina W von Einsiedel; Ingrid W Samorei; Michael Pawlita; Baerbel Zwissler; Max Deubel; Harry V Vinters
Journal:  J Neurovirol       Date:  2004-02       Impact factor: 2.643
View more
  34 in total

1.  JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.

Authors:  Tom Van Loy; Kim Thys; Caroline Ryschkewitsch; Ole Lagatie; Maria C Monaco; Eugene O Major; Luc Tritsmans; Lieven J Stuyver
Journal:  J Virol       Date:  2014-11-12       Impact factor: 5.103

Review 2.  Progressive multifocal leukoencephalopathy and newer biological agents.

Authors:  Joseph R Berger
Journal:  Drug Saf       Date:  2010-11-01       Impact factor: 5.606

3.  Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy.

Authors:  Juliene K G Co; Saguna Verma; Ulziijargal Gurjav; Laarni Sumibcay; Vivek R Nerurkar
Journal:  J Infect Dis       Date:  2007-07-20       Impact factor: 5.226

Review 4.  Progressive multifocal leukoencephalopathy.

Authors:  Joseph R Berger
Journal:  Curr Neurol Neurosci Rep       Date:  2007-11       Impact factor: 5.081

Review 5.  Virus infections in the nervous system.

Authors:  Orkide O Koyuncu; Ian B Hogue; Lynn W Enquist
Journal:  Cell Host Microbe       Date:  2013-04-17       Impact factor: 21.023

6.  ERK Is a Critical Regulator of JC Polyomavirus Infection.

Authors:  Jeanne K DuShane; Michael P Wilczek; Colleen L Mayberry; Melissa S Maginnis
Journal:  J Virol       Date:  2018-03-14       Impact factor: 5.103

7.  Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells.

Authors:  Moti L Chapagain; Laarni Sumibcay; Ulziijargal Gurjav; Pakieli H Kaufusi; Richard E Kast; Vivek R Nerurkar
Journal:  J Neurovirol       Date:  2008-11-12       Impact factor: 2.643

8.  Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.

Authors:  Saguna Verma; Mukesh Kumar; Ulziijargal Gurjav; Stephanie Lum; Vivek R Nerurkar
Journal:  Virology       Date:  2009-11-18       Impact factor: 3.616

9.  Human embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor and are susceptible to JC virus infection.

Authors:  C Schaumburg; B A O'Hara; T E Lane; W J Atwood
Journal:  J Virol       Date:  2008-06-25       Impact factor: 5.103

10.  Interferon beta1-a and selective anti-5HT(2a) receptor antagonists inhibit infection of human glial cells by JC virus.

Authors:  B A O'Hara; W J Atwood
Journal:  Virus Res       Date:  2008-03       Impact factor: 3.303
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.