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Literature DB >> 750371

Studies on the immune protection to murine experimental brucellosis conferred by Brucella fractions. I. Positive role of immune serum.

S Bascoul, A Cannat, M F Huguet, A Serre.

Abstract

Mouse inoculation with three different phenol-insoluble fractions extracted from Brucella melitensis (fractions 'PI', '4A' and '5') induces an acceleration of the blood clearance of i.v. inoculated live Brucella and a diminution of the rate of multiplication of the injected bacteria in the spleen. Preincubation of the challenge inoculum in immune serum or i.p. injections of immune serum confer a good specific protection to non-immunized hosts. The results observed with fractionated sera suggest that, not only antibodies, but also other serum constituents may participate in the protective activity of immune sera. This discussed in terms of the respective importance of humoral and cellular immunity to Brucella and of the choice of the best preparations for human or animal vaccination.

Entities: Chemical Disease Species

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Year: 1978 PMID： 750371 PMCID： PMC1457275

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

9 in total

1. Passive protection experiments with Brucella antisera.

Authors: D SULITZEANU
Journal: J Hyg (Lond) Date: 1955-06

2. [Immunological properties of a phenol-insoluble extract from Brucella melitensis (P.I. fraction)].

Authors: J Roux; J Asselineau; A Serre; C Lacave
Journal: Ann Inst Pasteur (Paris) Date: 1967-09

3. Conditions for production, and some characteristics, of mycobacterial growth inhibitory factor produced by spleen cells from mice immunized with viable cells of the attenuated H37Ra strain of Mycobacterium tuberculosis.

Authors: D L Cahall; G P Youmans
Journal: Infect Immun Date: 1975-10 Impact factor: 3.441

4. [Anti-brucellosis human vaccination with an antigenic fraction of Brucella melitensis].

Authors: J Roux; A Serre; J Asselineau; C Lacave
Journal: Bull Acad Natl Med Date: 1970 Apr-May Impact factor: 0.144

5. Serum-mediated immune cellular responses to Brucella melitensis REV 1. II. Restriction of Brucella by immune sera and macrophages.

Authors: D J Ralston; S S Elberg
Journal: J Reticuloendothel Soc Date: 1969-04

6. A purified killed Brucella abortus vaccine.

Authors: J Keppie; K Witt; H Smith
Journal: Br J Exp Pathol Date: 1971-08

7. Immunization against Brucella with killed vaccines. Immunizing activity in mice of Brucella cell walls and of fractions derived from them.

Authors: G Rasooly; A L Olitzki; D Sulitzeanu
Journal: Isr J Med Sci Date: 1966 Sep-Oct

8. Immunization by an insoluble fraction extracted from Brucella melitensis: immunological and chemical characterization of the active substances.

Authors: A Lopez-Merino; J Asselineau; A Serre; J Roux; S Bascoul; C Lacave
Journal: Infect Immun Date: 1976-02 Impact factor: 3.441

9. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.

Authors: G B MACKANESS
Journal: J Exp Med Date: 1964-07-01 Impact factor: 14.307

9 in total

18 in total

1. Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum.

Authors: L N Araya; A J Winter
Journal: Infect Immun Date: 1990-01 Impact factor: 3.441

10. Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.

Authors: M S Ascher; P B Jahrling; D G Harrington; R A Kishimoto; V G McGann
Journal: Clin Exp Immunol Date: 1980-08 Impact factor: 4.330

Studies on the immune protection to murine experimental brucellosis conferred by Brucella fractions. I. Positive role of immune serum.

1. Passive protection experiments with Brucella antisera.

2. [Immunological properties of a phenol-insoluble extract from Brucella melitensis (P.I. fraction)].

3. Conditions for production, and some characteristics, of mycobacterial growth inhibitory factor produced by spleen cells from mice immunized with viable cells of the attenuated H37Ra strain of Mycobacterium tuberculosis.

4. [Anti-brucellosis human vaccination with an antigenic fraction of Brucella melitensis].

5. Serum-mediated immune cellular responses to Brucella melitensis REV 1. II. Restriction of Brucella by immune sera and macrophages.

6. A purified killed Brucella abortus vaccine.

7. Immunization against Brucella with killed vaccines. Immunizing activity in mice of Brucella cell walls and of fractions derived from them.

8. Immunization by an insoluble fraction extracted from Brucella melitensis: immunological and chemical characterization of the active substances.

9. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.

1. Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum.

2. In-vitro and in-vivo immunobiological properties of murine monoclonal anti-Brucella antibodies.

3. Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice.

4. Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK).

5. Analysis of Brucella lipopolysaccharide with specific and cross-reacting monoclonal antibodies.

6. Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies.

7. Capacity of passively administered antibody to prevent establishment of Brucella abortus infection in mice.

8. Vaccine and serum-mediated protection against brucella infection of mouse placenta.

9. Biological properties of a panel of murine monoclonal anti-Brucella antibodies.

10. Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.