Literature DB >> 7503672

The serology of hepatitis C virus (HCV) infection: antibody crossreaction in the hypervariable region 1.

M da Silva Cardoso1, K Siemoneit, V Nemecek, S Epple, K Koerner, B Kubanek.   

Abstract

We determined the NS1/E2 N-terminal sequence including the hypervariable region 1 (HVR1) from five individuals chronically infected with HCV: two from the Czech Republic and three from Germany. From each sequence, six 12-mer overlapping peptides were synthesized and used in a peptide scan to evaluate seroreactivity of each of those patients, as well as three anti-HCV positive blood donors to the different isolates. We could show the general presence of antibodies to multiple HVR1 specific sequences reflecting the existence of multiple variants in infected persons. Finally, we observed the persistance of HCV infections in all individuals despite an active humoral response directed against the virus.

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Year:  1995        PMID： 7503672     DOI： 10.1007/bf01384335

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  16 in total

1.  Confirmation of hepatitis C virus positive blood donors by immunoblotting and polymerase chain reaction.

Authors:  H De Beenhouwer; H Verhaert; H Claeys; C Vermylen
Journal:  Vox Sang       Date:  1992       Impact factor: 2.144

2.  Hypervariable regions in the putative glycoprotein of hepatitis C virus.

Authors:  M Hijikata; N Kato; Y Ootsuyama; M Nakagawa; S Ohkoshi; K Shimotohno
Journal:  Biochem Biophys Res Commun       Date:  1991-02-28       Impact factor: 3.575

3.  A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody.

Authors:  S Taniguchi; H Okamoto; M Sakamoto; M Kojima; F Tsuda; T Tanaka; E Munekata; E E Muchmore; D A Peterson; S Mishiro
Journal:  Virology       Date:  1993-07       Impact factor: 3.616

4.  Hypervariable 5'-terminus of hepatitis C virus E2/NS1 encodes antigenically distinct variants.

Authors:  R R Lesniewski; K M Boardway; J M Casey; S M Desai; S G Devare; T K Leung; I K Mushahwar
Journal:  J Med Virol       Date:  1993-06       Impact factor: 2.327

5.  Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.

Authors:  N Kato; H Sekiya; Y Ootsuyama; T Nakazawa; M Hijikata; S Ohkoshi; K Shimotohno
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

6.  Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus.

Authors:  N Kato; Y Ootsuyama; S Ohkoshi; T Nakazawa; H Sekiya; M Hijikata; K Shimotohno
Journal:  Biochem Biophys Res Commun       Date:  1992-11-30       Impact factor: 3.575

7.  Genomic characterization and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic of non-A, non-B hepatitis in Japan.

Authors:  K Abe; G Inchauspe; K Fujisawa
Journal:  J Gen Virol       Date:  1992-10       Impact factor: 3.891

8.  Use of conserved sequences from hepatitis C virus for the detection of viral RNA in infected sera by polymerase chain reaction.

Authors:  G Inchauspe; K Abe; S Zebedee; M Nasoff; A M Prince
Journal:  Hepatology       Date:  1991-10       Impact factor: 17.425

9.  Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

Authors:  A J Weiner; H M Geysen; C Christopherson; J E Hall; T J Mason; G Saracco; F Bonino; K Crawford; C D Marion; K A Crawford
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

10.  Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution.

Authors:  M Martell; J I Esteban; J Quer; J Genescà; A Weiner; R Esteban; J Guardia; J Gómez
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103
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  3 in total

Review 1.  Immunopathogenesis of viral hepatitis.

Authors:  M U Mondelli
Journal:  Clin Rev Allergy Immunol       Date:  2000-04       Impact factor: 8.667

Review 2.  Variability or conservation of hepatitis C virus hypervariable region 1? Implications for immune responses.

Authors:  Mario U Mondelli; Antonella Cerino; Annalisa Meola; Alfredo Nicosia
Journal:  J Biosci       Date:  2003-04       Impact factor: 1.826

Review 3.  Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry.

Authors:  Jannick Prentoe; Jens Bukh
Journal:  Front Immunol       Date:  2018-09-27       Impact factor: 7.561
  3 in total

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