Literature DB >> 1847805

Hypervariable regions in the putative glycoprotein of hepatitis C virus.

M Hijikata1, N Kato, Y Ootsuyama, M Nakagawa, S Ohkoshi, K Shimotohno.   

Abstract

A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.

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Year:  1991        PMID： 1847805     DOI： 10.1016/s0006-291x(05)81223-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  79 in total

1.  New methods for detecting positive selection at single amino acid sites.

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2.  Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation.

Authors:  Weihua Wang; Jianguo Lin; De Tan; Yanjuan Xu; Elizabeth M Brunt; Xiaofeng Fan; Adrian M Di Bisceglie
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3.  Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

Authors:  M Hijikata; N Kato; Y Ootsuyama; M Nakagawa; K Shimotohno
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

4.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

5.  Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins.

Authors:  Benjamin O Fulton; David Sachs; Shannon M Beaty; Sohui T Won; Benhur Lee; Peter Palese; Nicholas S Heaton
Journal:  Cell Rep       Date:  2015-05-21       Impact factor: 9.423

6.  Long-term evolution of the hypervariable region of hepatitis C virus in a common-source-infected cohort.

Authors:  J McAllister; C Casino; F Davidson; J Power; E Lawlor; P L Yap; P Simmonds; D B Smith
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

Review 7.  The quasispecies of hepatitis C virus and the host immune response.

Authors:  P Farci; J Bukh; R H Purcell
Journal:  Springer Semin Immunopathol       Date:  1997

8.  Discrimination of hepatitis C virus in liver tissues from different patients with hepatocellular carcinomas by direct nucleotide sequencing of amplified cDNA of the viral genome.

Authors:  W H Chou; T Yoneyama; K Takeuchi; H Harada; I Saito; T Miyamura
Journal:  J Clin Microbiol       Date:  1991-12       Impact factor: 5.948

9.  Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.

Authors:  N Kato; H Sekiya; Y Ootsuyama; T Nakazawa; M Hijikata; S Ohkoshi; K Shimotohno
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

10.  Identification of a domain containing B-cell epitopes in hepatitis C virus E2 glycoprotein by using mouse monoclonal antibodies.

Authors:  J W Lee; K m Kim; S H Jung; K J Lee; E C Choi; Y C Sung; C Y Kang
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103
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