Literature DB >> 7502079

A Drosophila homolog of the yeast origin recognition complex.

M Gossen1, D T Pak, S K Hansen, J K Acharya, M R Botchan.   

Abstract

Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC). The abundance of the Drosophila Orc2p homolog DmORC2 is developmentally regulated and is greatest during the earliest stages of embryogenesis, concomitant with the highest rate of DNA replication. Fractionation of embryo nuclear extracts revealed that DmORC2 is found in a tightly associated complex with five additional polypeptides, much like the yeast ORC. These studies will enable direct testing of the initiator-based model of replication in a metazoan.

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Year:  1995        PMID： 7502079     DOI： 10.1126/science.270.5242.1674

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  55 in total

1.  Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.

Authors:  Y Ogawa; T Takahashi; H Masukata
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

Authors:  L Lu; H Zhang; J Tower
Journal:  Genes Dev       Date:  2001-01-15       Impact factor: 11.361

3.  E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.

Authors:  M Asano; R P Wharton
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

4.  Functional analysis of mutant and wild-type Drosophila origin recognition complex.

Authors:  I Chesnokov; D Remus; M Botchan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

5.  Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.

Authors:  I Chesnokov; M Gossen; D Remus; M Botchan
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

6.  The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene product.

Authors:  D DeRyckere; C L Smith; G S Martin
Journal:  Genetics       Date:  1999-04       Impact factor: 4.562

7.  Characterization of a novel origin recognition complex-like complex: implications for DNA recognition, cell cycle control, and locus-specific gene amplification.

Authors:  Mohammad Mohammad; Randall D York; Jonathan Hommel; Geoffrey M Kapler
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

8.  Sequence-independent DNA binding and replication initiation by the human origin recognition complex.

Authors:  Sanjay Vashee; Christin Cvetic; Wenyan Lu; Pamela Simancek; Thomas J Kelly; Johannes C Walter
Journal:  Genes Dev       Date:  2003-08-01       Impact factor: 11.361

9.  Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7.

Authors:  N Sato; K Arai; H Masai
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

10.  Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.

Authors:  Tina Baldinger; Manfred Gossen
Journal:  Mol Cell Biol       Date:  2008-10-27       Impact factor: 4.272
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