Infantile acute hemorrhagic edema: a variant of leukocytoclastic vasculitis.

Infantile acute hemorrhagic edema (IAHE) is a leukocytoclastic vasculitis that is confined to the skin without visceral involvement. Edema and purpuric lesions characterize the disease. The disorder has a dramatic onset, with a short, benign course and spontaneous resolution within several weeks. The clinical similarities between IAHE and Henoch-Shönlein purpura have been discussed in the literature. We report three infants with IAHE and discuss the clinical, laboratory, and histopathologic features of the disease. We suggest that it should be regarded as a separate entity for appropriate diagnostic investigations and therapy.