Literature DB >> 7500868

In vivo localized proton NMR spectroscopy of thiamine-deficient rat brain.

H Lee1, J Tarter, G E Holburn, R R Price, D D Weinstein, P R Martin.   

Abstract

Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague-Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine-deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 +/- 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose-dependent recovery in Cho/NAA was observed.

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Year:  1995        PMID： 7500868     DOI： 10.1002/mrm.1910340306

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  7 in total

1.  Proton MR spectroscopy in Wernicke encephalopathy.

Authors:  Carlos A Rugilo; Marcela C Uribe Roca; Maria C Zurru; Arístides A Capizzano; Gustavo A Pontello; Emilia M Gatto
Journal:  AJNR Am J Neuroradiol       Date:  2003-05       Impact factor: 3.825

2.  Proton MR spectroscopy of Wernicke encephalopathy.

Authors:  Mario Mascalchi; Giacomo Belli; Laura Guerrini; Marco Nistri; Ines Del Seppia; Natale Villari
Journal:  AJNR Am J Neuroradiol       Date:  2002 Nov-Dec       Impact factor: 3.825

3.  In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage.

Authors:  Natalie M Zahr; Dirk Mayer; Shara Vinco; Juan Orduna; Richard Luong; Edith V Sullivan; Adolf Pfefferbaum
Journal:  Neuropsychopharmacology       Date:  2008-08-13       Impact factor: 7.853

4.  Concomitants of alcoholism: differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo.

Authors:  Natalie M Zahr; Edith V Sullivan; Torsten Rohlfing; Dirk Mayer; Amy M Collins; Richard Luong; Adolf Pfefferbaum
Journal:  Psychopharmacology (Berl)       Date:  2016-04-30       Impact factor: 4.530

5.  Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy.

Authors:  Natalie M Zahr; Carsten Alt; Dirk Mayer; Torsten Rohlfing; Amy Manning-Bog; Richard Luong; Edith V Sullivan; Adolf Pfefferbaum
Journal:  Exp Neurol       Date:  2014-06-25       Impact factor: 5.330

Review 6.  Susceptibility of the cerebellum to thiamine deficiency.

Authors:  Patrick J Mulholland
Journal:  Cerebellum       Date:  2006       Impact factor: 3.648

Review 7.  Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.

Authors:  Natalie M Zahr; Adolf Pfefferbaum
Journal:  Alcohol Res       Date:  2017
  7 in total

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