Literature DB >> 7498449

Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells.

I Silvestri1, L Albonici, M Ciotti, M P Lombardi, P Sinibaldi, V Manzari, P Orlando, F Carretta, G Strazzullo, P Grippo.   

Abstract

Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.

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Year:  1995        PMID： 7498449     DOI： 10.1007/bf01946920

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

Authors:  J Inoue; M Yoshida; M Seiki
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

2.  Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

Authors:  T Kinoshita; M Shimoyama; K Tobinai; M Ito; S Ito; S Ikeda; K Tajima; K Shimotohno; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

Review 3.  Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact.

Authors:  E De Clercq
Journal:  Adv Virus Res       Date:  1993       Impact factor: 9.937

4.  Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.

Authors:  I Miyoshi; I Kubonishi; S Yoshimoto; T Akagi; Y Ohtsuki; Y Shiraishi; K Nagata; Y Hinuma
Journal:  Nature       Date:  1981-12-24       Impact factor: 49.962

5.  Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Authors:  G T Tan; J M Pezzuto; A D Kinghorn; S H Hughes
Journal:  J Nat Prod       Date:  1991 Jan-Feb       Impact factor: 4.050

6.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Authors:  M Yoshida; I Miyoshi; Y Hinuma
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

7.  Homology of human T-cell leukaemia virus envelope gene with class I HLA gene.

Authors:  M F Clarke; E P Gelmann; M S Reitz
Journal:  Nature       Date:  1983 Sep 1-7       Impact factor: 49.962

8.  Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.

Authors:  M Popovic; G Lange-Wantzin; P S Sarin; D Mann; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

9.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

10.  Kelletinin I and kelletinin A from the marine mollusc Buccinulum corneum are inhibitors of eukaryotic DNA polymerase alpha.

Authors:  P Orlando; F Carretta; P Grippo; G Cimino; S De Stefano; G Strazzullo
Journal:  Experientia       Date:  1991-01-15
  10 in total
  3 in total

Review 1.  Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs.

Authors:  Vinh T Dang; Kirsten Benkendorff; Tim Green; Peter Speck
Journal:  J Virol       Date:  2015-06-10       Impact factor: 5.103

2.  Inhibition mechanisms of HIV-1, Mo-MuLV and AMV reverse transcriptases by Kelletinin A from Buccinulum corneum.

Authors:  P Orlando; G Strazzullo; F Carretta; M De Falco; P Grippo
Journal:  Experientia       Date:  1996-08-15

Review 3.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411
  3 in total

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