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Literature DB >> 7496909

Transforming growth factor beta in Alzheimer's disease.

C C Chao¹, S Hu, W H Frey, T A Ala, W W Tourtellotte, P K Peterson.

Abstract

Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7496909 PMCID： PMC368205 DOI： 10.1128/cdli.1.1.109-110.1994

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

14 in total

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Authors: S Strauss; J Bauer; U Ganter; U Jonas; M Berger; B Volk
Journal: Lab Invest Date: 1992-02 Impact factor: 5.662

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Journal: Prog Growth Factor Res Date: 1991

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Journal: Biochem Biophys Res Commun Date: 1990-09-14 Impact factor: 3.575

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Journal: J Immunol Date: 1991-05-01 Impact factor: 5.422

5. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.

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Journal: Neurology Date: 1984-07 Impact factor: 9.910

6. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome.

Authors: C C Chao; E N Janoff; S X Hu; K Thomas; M Gallagher; M Tsang; P K Peterson
Journal: Cytokine Date: 1991-07 Impact factor: 3.861

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Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

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Authors: H Fillit; W H Ding; L Buee; J Kalman; L Altstiel; B Lawlor; G Wolf-Klein
Journal: Neurosci Lett Date: 1991-08-19 Impact factor: 3.046

9. Cytokines in Alzheimer's disease.

Authors: L D Altstiel; K Sperber
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 1991 Impact factor: 5.067

10. Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes.

Authors: B Saad; D B Constam; R Ortmann; M Moos; A Fontana; M Schachner
Journal: J Cell Biol Date: 1991-10 Impact factor: 10.539

37 in total

1. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.

Authors: T Wyss-Coray; C Lin; D A Sanan; L Mucke; E Masliah
Journal: Am J Pathol Date: 2000-01 Impact factor: 4.307

2. TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity.

Authors: Pirooz Eslami; Ming F Johnson; Ellen Terzakaryan; Carolyn Chew; Marni E Harris-White
Journal: Brain Res Date: 2008-09-10 Impact factor: 3.252

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Journal: J Neurosci Date: 1998-12-15 Impact factor: 6.167

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Journal: Neurobiol Aging Date: 2000 May-Jun Impact factor: 4.673