Literature DB >> 7494309

Human cytomegalovirus IE1 and IE2 proteins block apoptosis.

H Zhu1, Y Shen, T Shenk.   

Abstract

Human cytomegalovirus-infected fibroblasts are resistant to the induction of apoptosis by superinfection with a mutant adenovirus unable to produce the viral E1B 19-kDa protein that normally causes an E1A protein-mediated apoptotic response. Two cytomegalovirus gene products that block apoptosis were identified. The IE1 and IE2 proteins each inhibit the induction of apoptosis by tumor necrosis factor alpha or by the E1B 19-kDa-protein-deficient adenovirus but not by irradiation with UV light. Our results suggest a new physiological role for the IE1 and IE2 proteins in the human cytomegalovirus replication cycle.

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Year:  1995        PMID： 7494309      PMCID： PMC189741     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  63 in total

1.  Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins.

Authors:  C L Malone; D H Vesole; M F Stinski
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

2.  Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.

Authors:  S N Farrow; J H White; I Martinou; T Raven; K T Pun; C J Grinham; J C Martinou; R Brown
Journal:  Nature       Date:  1995-04-20       Impact factor: 49.962

3.  An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.

Authors:  J G Neilan; Z Lu; C L Afonso; G F Kutish; M D Sussman; D L Rock
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

4.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

Authors:  D B Smith; K S Johnson
Journal:  Gene       Date:  1988-07-15       Impact factor: 3.688

5.  Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein.

Authors:  M H Sommer; A L Scully; D H Spector
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

6.  Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.

Authors:  E Yang; J Zha; J Jockel; L H Boise; C B Thompson; S J Korsmeyer
Journal:  Cell       Date:  1995-01-27       Impact factor: 41.582

7.  Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein.

Authors:  N C Reich; P Sarnow; E Duprey; A J Levine
Journal:  Virology       Date:  1983-07-30       Impact factor: 3.616

8.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

Authors:  J Yuan; S Shaham; S Ledoux; H M Ellis; H R Horvitz
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

9.  Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

Authors:  C Hagemeier; R Caswell; G Hayhurst; J Sinclair; T Kouzarides
Journal:  EMBO J       Date:  1994-06-15       Impact factor: 11.598

10.  The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation.

Authors:  R Caswell; C Hagemeier; C J Chiou; G Hayward; T Kouzarides; J Sinclair
Journal:  J Gen Virol       Date:  1993-12       Impact factor: 3.891
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  203 in total

1.  A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

Authors:  V S Goldmacher; L M Bartle; A Skaletskaya; C A Dionne; N L Kedersha; C A Vater; J W Han; R J Lutz; S Watanabe; E D Cahir McFarland; E D Kieff; E S Mocarski; T Chittenden
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

2.  Characterization of a human cytomegalovirus with phosphorylation site mutations in the immediate-early 2 protein.

Authors:  Julie A Heider; Yongjun Yu; Thomas Shenk; James C Alwine
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

3.  Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication.

Authors:  Veronica Sanchez; Charles L Clark; Judy Y Yen; Roopashree Dwarakanath; Deborah H Spector
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

4.  A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.

Authors:  A Skaletskaya; L M Bartle; T Chittenden; A L McCormick; E S Mocarski; V S Goldmacher
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

5.  The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle.

Authors:  Robert F Kalejta; Thomas Shenk
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

6.  Disruption of mitochondrial networks by the human cytomegalovirus UL37 gene product viral mitochondrion-localized inhibitor of apoptosis.

Authors:  A Louise McCormick; Vanessa L Smith; Dar Chow; Edward S Mocarski
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

7.  Role of human cytomegalovirus immediate-early proteins in cell growth control.

Authors:  J P Castillo; A D Yurochko; T F Kowalik
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

8.  Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.

Authors:  L R Bonin; J K McDougall
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

9.  Incoming human cytomegalovirus pp65 (UL83) contained in apoptotic infected fibroblasts is cross-presented to CD8(+) T cells by dendritic cells.

Authors:  G Arrode; C Boccaccio; J Lulé; S Allart; N Moinard; J P Abastado; A Alam; C Davrinche
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

10.  Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.

Authors:  Michael Nevels; Christina Paulus; Thomas Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-30       Impact factor: 11.205
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