OBJECTIVE: To evaluate response to chemotherapy in cats with alimentary lymphoma and to determine factors associated with survival time. DESIGN: Retrospective case series. ANIMALS: 28 cats with alimentary lymphoma that underwent chemotherapy. RESULTS: In all cats, the diagnosis had been established by means of cytologic or histologic examination of ultrasound-guided aspirates and biopsy specimens (18 cats), histologic examination of surgically obtained biopsy specimens (7 cats), or examination of specimens obtained endoscopically (3 cats). Clinical signs included anorexia, weight loss, vomiting, and diarrhea. Twenty-seven cats were treated with vincristine sulfate, cyclophosphamide, and prednisone; 1 was treated with chlorambucil and prednisone. Survival time ranged from 2 to 2,120 days (median, 50 days). Nine cats achieved complete remission (remission time ranged from 30 to 1,700 days; median, 213 days), 2 achieved partial remission, and 17 failed to respond to chemotherapy. Sex, FeLV status, hematocrit, serum total protein concentration, site and extent of gastrointestinal involvement, and clinical stage were not found to be associated with survival time. CLINICAL IMPLICATIONS: Cats with alimentary lymphoma are poorly responsive to treatment with vincristine, cyclophosphamide, and prednisone; however, a small subset of cats may have long survival times.
OBJECTIVE: To evaluate response to chemotherapy in cats with alimentary lymphoma and to determine factors associated with survival time. DESIGN: Retrospective case series. ANIMALS: 28 cats with alimentary lymphoma that underwent chemotherapy. RESULTS: In all cats, the diagnosis had been established by means of cytologic or histologic examination of ultrasound-guided aspirates and biopsy specimens (18 cats), histologic examination of surgically obtained biopsy specimens (7 cats), or examination of specimens obtained endoscopically (3 cats). Clinical signs included anorexia, weight loss, vomiting, and diarrhea. Twenty-seven cats were treated with vincristine sulfate, cyclophosphamide, and prednisone; 1 was treated with chlorambucil and prednisone. Survival time ranged from 2 to 2,120 days (median, 50 days). Nine cats achieved complete remission (remission time ranged from 30 to 1,700 days; median, 213 days), 2 achieved partial remission, and 17 failed to respond to chemotherapy. Sex, FeLV status, hematocrit, serum total protein concentration, site and extent of gastrointestinal involvement, and clinical stage were not found to be associated with survival time. CLINICAL IMPLICATIONS: Cats with alimentary lymphoma are poorly responsive to treatment with vincristine, cyclophosphamide, and prednisone; however, a small subset of cats may have long survival times.
Authors: K W Simpson; D Strauss-Ayali; E Scanziani; R K Straubinger; P L McDonough; A F Straubinger; Y F Chang; C Domeneghini; N Arebi; J Calam Journal: Infect Immun Date: 2000-02 Impact factor: 3.441
Authors: S A Collette; S D Allstadt; E M Chon; W Vernau; A N Smith; L D Garrett; K Choy; R B Rebhun; C O Rodriguez; K A Skorupski Journal: Vet Comp Oncol Date: 2015-06-25 Impact factor: 2.613
Authors: Reinhard K Straubinger; Andrea Greiter; Sean P McDonough; Alexander Gerold; Eugenio Scanziani; Sabina Soldati; Daiva Dailidiene; Giedrius Dailide; Douglas E Berg; Kenneth W Simpson Journal: Infect Immun Date: 2003-05 Impact factor: 3.441
Authors: Lise A Daniaux; Michele P Laurenson; Stanley L Marks; Peter F Moore; Sandra L Taylor; Rachel X Chen; Allison L Zwingenberger Journal: J Feline Med Surg Date: 2013-07-30 Impact factor: 2.015
Authors: M I Esteves; M D Schrenzel; R P Marini; N S Taylor; S Xu; S Hagen; Y Feng; Z Shen; J G Fox Journal: Am J Pathol Date: 2000-02 Impact factor: 4.307