| Literature DB >> 26109275 |
S A Collette1,2, S D Allstadt3,4, E M Chon5, W Vernau6, A N Smith7, L D Garrett8, K Choy9,10, R B Rebhun3, C O Rodriguez3, K A Skorupski3.
Abstract
CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).Entities:
Keywords: CHOP; cat; feline; lymphoma; maintenance-free chemotherapy; survival
Mesh：
Substances：
Year: 2015 PMID： 26109275 PMCID： PMC5012421 DOI： 10.1111/vco.12158
Source DB: PubMed Journal: Vet Comp Oncol ISSN： 1476-5810 Impact factor: 2.613