Literature DB >> 7492786

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

S P Romana1, H Poirel, M Leconiat, M A Flexor, M Mauchauffé, P Jonveaux, E A Macintyre, R Berger, O A Bernard.   

Abstract

The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B-lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7492786

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  60 in total

1.  Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.

Authors:  R Fenrick; J M Amann; B Lutterbach; L Wang; J J Westendorf; J R Downing; S W Hiebert
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.

Authors:  L Van Rompaey; W Dou; A Buijs; G Grosveld
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

3.  Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).

Authors:  T L Gu; T L Goetz; B J Graves; N A Speck
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

4.  The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

Authors:  S W Hiebert; W Sun; J N Davis; T Golub; S Shurtleff; A Buijs; J R Downing; G Grosveld; M F Roussell; D G Gilliland; N Lenny; S Meyers
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

Review 5.  Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.

Authors:  Adwitiya Kar; Arthur Gutierrez-Hartmann
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-09-25       Impact factor: 8.250

6.  The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

Authors:  F Salomon-Nguyen; V Della-Valle; M Mauchauffe; M Busson-Le Coniat; J Ghysdael; R Berger; O A Bernard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

7.  Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information.

Authors:  B J Bain
Journal:  J Clin Pathol       Date:  1998-06       Impact factor: 3.411

8.  RT-PCR and real-time PCR analysis of E2A-PBX1, TEL-AML1, mBCR-ABL and MLL-AF4 fusion gene transcripts in de novo B-lineage acute lymphoblastic leukaemia patients in south India.

Authors:  Natarajan Sudhakar; Kamalalayam Raghavan Rajalekshmy; Thangarajan Rajkumar; Karunakaran Nirmala Nancy
Journal:  J Genet       Date:  2011-08       Impact factor: 1.166

9.  The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Authors:  Monica Cardone; Ayten Kandilci; Cintia Carella; Jonas A Nilsson; Jennifer A Brennan; Sema Sirma; Ugur Ozbek; Kelli Boyd; John L Cleveland; Gerard C Grosveld
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

10.  The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor.

Authors:  Iver Nordentoft; Poul Jørgensen
Journal:  Biochem J       Date:  2003-08-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.