Literature DB >> 7492120

The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

S Keynan1, N M Hooper, A Felici, G Amicosante, A J Turner.   

Abstract

The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP; dehydropeptidase I). Both enzymes are able to hydrolyze imipenem and are inhibited by cilastatin. The active site similarities of these enzymes are not reflected in any significant primary sequence similarity.

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Year:  1995        PMID： 7492120      PMCID： PMC162797          DOI： 10.1128/AAC.39.7.1629

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Sequence analysis of the L1 metallo-beta-lactamase from Xanthomonas maltophilia.

Authors:  T R Walsh; L Hall; S J Assinder; W W Nichols; S J Cartwright; A P MacGowan; P M Bennett
Journal:  Biochim Biophys Acta       Date:  1994-06-21

2.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

3.  High specificity of cphA-encoded metallo-beta-lactamase from Aeromonas hydrophila AE036 for carbapenems and its contribution to beta-lactam resistance.

Authors:  B Segatore; O Massidda; G Satta; D Setacci; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

4.  Kinetic analysis of extension of substrate specificity with Xanthomonas maltophilia, Aeromonas hydrophila, and Bacillus cereus metallo-beta-lactamases.

Authors:  A Felici; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

5.  Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

Authors:  J S Kahan; F M Kahan; R Goegelman; S A Currie; M Jackson; E O Stapley; T W Miller; A K Miller; D Hendlin; S Mochales; S Hernandez; H B Woodruff; J Birnbaum
Journal:  J Antibiot (Tokyo)       Date:  1979-01       Impact factor: 2.649

Review 6.  Thienamycin: development of imipenen-cilastatin.

Authors:  F M Kahan; H Kropp; J G Sundelof; J Birnbaum
Journal:  J Antimicrob Chemother       Date:  1983-12       Impact factor: 5.790

7.  Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity.

Authors:  S Keynan; N M Hooper; A J Turner
Journal:  FEBS Lett       Date:  1994-07-25       Impact factor: 4.124

8.  Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase.

Authors:  H Kropp; J G Sundelof; R Hajdu; F M Kahan
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

9.  Cloning and sequencing of the metallothioprotein beta-lactamase II gene of Bacillus cereus 569/H in Escherichia coli.

Authors:  M Hussain; A Carlino; M J Madonna; J O Lampen
Journal:  J Bacteriol       Date:  1985-10       Impact factor: 3.490

10.  An X-ray-crystallographic study of beta-lactamase II from Bacillus cereus at 0.35 nm resolution.

Authors:  B J Sutton; P J Artymiuk; A E Cordero-Borboa; C Little; D C Phillips; S G Waley
Journal:  Biochem J       Date:  1987-11-15       Impact factor: 3.857
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  8 in total

1.  Carbapenem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases.

Authors:  R Nagano; Y Adachi; H Imamura; K Yamada; T Hashizume; H Morishima
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

2.  Cilastatin does not affect Carba NP test performance for detection of carbapenemase production in Enterobacteriaceae.

Authors:  Rainer Hartl; Sarah Widhalm; Heidrun Kerschner; Petra Apfalter; Rainer Gattringer
Journal:  Wien Klin Wochenschr       Date:  2016-10-28       Impact factor: 1.704

3.  Functional analysis of the active site of a metallo-beta-lactamase proliferating in Japan.

Authors:  S Haruta; H Yamaguchi; E T Yamamoto; Y Eriguchi; M Nukaga; K O'Hara; T Sawai
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

4.  Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases.

Authors:  A Felici; M Perilli; N Franceschini; G M Rossolini; M Galleni; J M Frere; A Oratore; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

5.  Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase.

Authors:  S Keynan; N M Hooper; A J Turner
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

6.  Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.

Authors:  Rosemary A Croft; James J Mousseau; Chulho Choi; James A Bull
Journal:  Chemistry       Date:  2017-12-20       Impact factor: 5.236

7.  Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin.

Authors:  Maria Agudelo; Carlos A Rodriguez; Andres F Zuluaga; Omar Vesga
Journal:  PLoS One       Date:  2019-02-06       Impact factor: 3.240

8.  Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

Authors:  Ioanna Tachmazidou; Konstantinos Hatzikotoulas; Lorraine Southam; Jorge Esparza-Gordillo; Valeriia Haberland; Jie Zheng; Toby Johnson; Mine Koprulu; Eleni Zengini; Julia Steinberg; Jeremy M Wilkinson; Sahir Bhatnagar; Joshua D Hoffman; Natalie Buchan; Dániel Süveges; Laura Yerges-Armstrong; George Davey Smith; Tom R Gaunt; Robert A Scott; Linda C McCarthy; Eleftheria Zeggini
Journal:  Nat Genet       Date:  2019-01-21       Impact factor: 38.330
  8 in total

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