Literature DB >> 7490330

Hepatitis C virus replication in hepatocellular carcinoma.

J Niu1, U Kumar, J Monjardino, R Goldin, D Rosin, H C Thomas.   

Abstract

Hepatitis C virus (HCV) replication is reported in both tumour and non-tumour tissue in a case of hepatocellular carcinoma. Viral replication was established by showing the presence of minus strand HCV RNA by PCR amplification, after excluding residual reverse transcriptase activity of Taq polymerase. No minus strand was found in serum derived virion RNA. PCR amplified products from both tumour and non-tumour parenchyma were sequenced in the 5' non-coding region and shown to be identical. The genotype of this Indonesian patient was found to be 1b (or II), the most prevalent type in the Far East.

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Year:  1995        PMID： 7490330      PMCID： PMC502885          DOI： 10.1136/jcp.48.9.880

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  Analysis of hepatitis C virus genotypes by a line probe assay and correlation with antibody profiles.

Authors:  L J van Doorn; B Kleter; L Stuyver; G Maertens; H Brouwer; S Schalm; R Heijtink; W Quint
Journal:  J Hepatol       Date:  1994-07       Impact factor: 25.083

2.  Discrimination of hepatitis C virus in liver tissues from different patients with hepatocellular carcinomas by direct nucleotide sequencing of amplified cDNA of the viral genome.

Authors:  W H Chou; T Yoneyama; K Takeuchi; H Harada; I Saito; T Miyamura
Journal:  J Clin Microbiol       Date:  1991-12       Impact factor: 5.948

3.  Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma.

Authors:  M Colombo; G Kuo; Q L Choo; M F Donato; E Del Ninno; M A Tommasini; N Dioguardi; M Houghton
Journal:  Lancet       Date:  1989-10-28       Impact factor: 79.321

4.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

5.  Detection of replicative hepatitis C virus sequences in hepatocellular carcinoma.

Authors:  M A Gerber; Y S Shieh; K S Shim; S N Thung; A J Demetris; M Schwartz; G Akyol; S Dash
Journal:  Am J Pathol       Date:  1992-12       Impact factor: 4.307

6.  Serological response and detection of viraemia in acute hepatitis C virus infection.

Authors:  S Dourakis; J Brown; U Kumar; P Karayiannis; P Kernoff; J Chiba; H Ohba; T Miyamura; I Saito; J Monjardino
Journal:  J Hepatol       Date:  1992-03       Impact factor: 25.083

7.  Hepatitis C virus infection in hepatocellular carcinoma. Detection of plus-strand and minus-strand viral RNA.

Authors:  S Takeda; M Shibata; T Morishima; A Harada; A Nakao; H Takagi; Y Nagai
Journal:  Cancer       Date:  1992-11-01       Impact factor: 6.860

8.  Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity.

Authors:  P Simmonds; F McOmish; P L Yap; S W Chan; C K Lin; G Dusheiko; A A Saeed; E C Holmes
Journal:  J Gen Virol       Date:  1993-04       Impact factor: 3.891

9.  Sequence variation in the large envelope glycoprotein (E2/NS1) of hepatitis C virus during chronic infection.

Authors:  U Kumar; J Brown; J Monjardino; H C Thomas
Journal:  J Infect Dis       Date:  1993-03       Impact factor: 5.226

10.  Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line.

Authors:  Y K Shimizu; A Iwamoto; M Hijikata; R H Purcell; H Yoshikura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205
  10 in total
  1 in total

1.  Treatment Status of Hepatocellular Carcinoma Does Not Influence Rates of Sustained Virologic Response: An HCV-TARGET Analysis.

Authors:  Kavita Radhakrishnan; Adrian M Di Bisceglie; K Rajender Reddy; Joseph K Lim; Josh Levitsky; Mohamed A Hassan; Jama M Darling; Jordan J Feld; Lucy Akushevich; Monika Vainorius; David R Nelson; Michael W Fried; Robert S Brown; Norah A Terrault
Journal:  Hepatol Commun       Date:  2019-08-07
  1 in total

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