Literature DB >> 7489507

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

L E Maquat1.   

Abstract

It appears that no organism is immune to the effects of nonsense codons on mRNA abundance. The study of how nonsense codons alter RNA metabolism is still at an early stage, and our current understanding derives more from incidental vignettes than from experimental undertakings that address molecular mechanisms. Challenges for the future include identifying the gene products and RNA sequences that function in nonsense mediated RNA loss, resolving the cause and consequences of there apparently being more than one cellular site and mechanism for nonsense-mediated RNA loss, and understanding how these sites and mechanisms are related to both constitutive and specialized pathways of pre-mRNA processing and mRNA decay.

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Year:  1995        PMID： 7489507      PMCID： PMC1482424     

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  103 in total

1.  CFTR nonsense mutations G542X and W1282X associated with severe reduction of CFTR mRNA in nasal epithelial cells.

Authors:  A Hamosh; B J Rosenstein; G R Cutting
Journal:  Hum Mol Genet       Date:  1992-10       Impact factor: 6.150

2.  A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

Authors:  C J Decker; R Parker
Journal:  Genes Dev       Date:  1993-08       Impact factor: 11.361

3.  Analysis of factor VIII mRNA reveals defects in everyone of 28 haemophilia A patients.

Authors:  J A Naylor; P M Green; C R Rizza; F Giannelli
Journal:  Hum Mol Genet       Date:  1993-01       Impact factor: 6.150

4.  A nonsense mutation and exon skipping in the Fanconi anaemia group C gene.

Authors:  R A Gibson; A Hajianpour; M Murer-Orlando; M Buchwald; C G Mathew
Journal:  Hum Mol Genet       Date:  1993-06       Impact factor: 6.150

5.  Molecular analysis of Hurler syndrome in Druze and Muslim Arab patients in Israel: multiple allelic mutations of the IDUA gene in a small geographic area.

Authors:  G Bach; S M Moskowitz; P T Tieu; A Matynia; E F Neufeld
Journal:  Am J Hum Genet       Date:  1993-08       Impact factor: 11.025

6.  Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells.

Authors:  A M Carothers; G Urlaub; D Grunberger; L A Chasin
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

7.  Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

Authors:  C L Hsu; A Stevens
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

Review 8.  Regulation of selenoproteins.

Authors:  R F Burk; K E Hill
Journal:  Annu Rev Nutr       Date:  1993       Impact factor: 11.848

9.  Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

Authors:  F He; S W Peltz; J L Donahue; M Rosbash; A Jacobson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

10.  Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia.

Authors:  L E Maquat; A J Kinniburgh; E A Rachmilewitz; J Ross
Journal:  Cell       Date:  1981-12       Impact factor: 41.582
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  192 in total

1.  Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.

Authors:  G Neu-Yilik; N H Gehring; R Thermann; U Frede; M W Hentze; A E Kulozik
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

2.  Null alleles of the COL5A1 gene of type V collagen are a cause of the classical forms of Ehlers-Danlos syndrome (types I and II).

Authors:  U Schwarze; M Atkinson; G G Hoffman; D S Greenspan; P H Byers
Journal:  Am J Hum Genet       Date:  2000-05-04       Impact factor: 11.025

3.  Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions.

Authors:  H Le Hir; M J Moore; L E Maquat
Journal:  Genes Dev       Date:  2000-05-01       Impact factor: 11.361

4.  Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.

Authors:  F Ringpfeil; M G Lebwohl; A M Christiano; J Uitto
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

5.  Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria.

Authors:  Y Bai; R M Shakeley; G Attardi
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

6.  The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

Authors:  H Le Hir; E Izaurralde; L E Maquat; M J Moore
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

7.  An exon that prevents transport of a mature mRNA.

Authors:  M A MacMorris; D A Zorio; T Blumenthal
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

8.  A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner.

Authors:  A Gersappe; D J Pintel
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

9.  Multiple splicing defects in an intronic false exon.

Authors:  H Sun; L A Chasin
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

10.  Stop codons affect 5' splice site selection by surveillance of splicing.

Authors:  Binghui Li; Chaim Wachtel; Elana Miriami; Galit Yahalom; Gilgi Friedlander; Gil Sharon; Ruth Sperling; Joseph Sperling
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205
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