OBJECTIVES: To investigate the circadian pattern of acute myocardial infarction in non-insulin-dependent diabetic patients and to compare it with that of controls. BACKGROUND: Previous studies have shown that there is a circadian variation in the incidence of acute myocardial infarction, but there are few data on diabetic subjects. METHODS: A hospital based prospective case-control study. RESULTS: 196 diabetic patients and 196 age and sex matched controls were admitted with a diagnosis of acute myocardial infarction during the study period. IN 32 diabetic patients and 38 controls, the time of onset of myocardial infarction was unknown; in 34, 44, 42, and 44 diabetic patients the onset was in the first to fourth quarters respectively (chi 2 = 1.66, NS). The corresponding figures for the controls were 30, 56, 45, and 27 (chi 2 = 13.9, P < 0.005). The difference between the two groups was highly significant (chi 2 = 10.3, P < 0.025). CONCLUSIONS: Diabetic subjects do not show a significant circadian variation in the onset of acute myocardial infarction.
OBJECTIVES: To investigate the circadian pattern of acute myocardial infarction in non-insulin-dependent diabeticpatients and to compare it with that of controls. BACKGROUND: Previous studies have shown that there is a circadian variation in the incidence of acute myocardial infarction, but there are few data on diabetic subjects. METHODS: A hospital based prospective case-control study. RESULTS: 196 diabeticpatients and 196 age and sex matched controls were admitted with a diagnosis of acute myocardial infarction during the study period. IN 32 diabeticpatients and 38 controls, the time of onset of myocardial infarction was unknown; in 34, 44, 42, and 44 diabeticpatients the onset was in the first to fourth quarters respectively (chi 2 = 1.66, NS). The corresponding figures for the controls were 30, 56, 45, and 27 (chi 2 = 13.9, P < 0.005). The difference between the two groups was highly significant (chi 2 = 10.3, P < 0.025). CONCLUSIONS:Diabetic subjects do not show a significant circadian variation in the onset of acute myocardial infarction.
Authors: J E Muller; P H Stone; Z G Turi; J D Rutherford; C A Czeisler; C Parker; W K Poole; E Passamani; R Roberts; T Robertson Journal: N Engl J Med Date: 1985-11-21 Impact factor: 91.245
Authors: G H Tofler; D Brezinski; A I Schafer; C A Czeisler; J D Rutherford; S N Willich; R E Gleason; G H Williams; J E Muller Journal: N Engl J Med Date: 1987-06-11 Impact factor: 91.245
Authors: Madhu J Prasai; Romana S Mughal; Stephen B Wheatcroft; Mark T Kearney; Peter J Grant; Eleanor M Scott Journal: Diabetes Date: 2013-02-04 Impact factor: 9.461