K Fujimoto1. 1. Department of Anatomy, Kawasaki Medical School, Okayama, Japan.
Abstract
BACKGROUND: Fine structural study revealed the intercellular coupling between the pericyte and the endothelial cells via the gap junctions, in the capillaries of the basal forebrain of rat embryos. RESULTS: Gap junctions were constructed by the adluminal plasmalemma of pericyte and the abluminal plasmalemma of endothelial cells. CONCLUSIONS: Gap junctions are membranous channels that directly join the cytoplasms of the pericyte and endothelial cell and imply some substantial role for the pericyte on the endothelial proliferation. It is postulated that the function of the pericyte in the prenatal mammals are assigned to the regulation of the development of cerebral microcirculation.
BACKGROUND: Fine structural study revealed the intercellular coupling between the pericyte and the endothelial cells via the gap junctions, in the capillaries of the basal forebrain of rat embryos. RESULTS: Gap junctions were constructed by the adluminal plasmalemma of pericyte and the abluminal plasmalemma of endothelial cells. CONCLUSIONS: Gap junctions are membranous channels that directly join the cytoplasms of the pericyte and endothelial cell and imply some substantial role for the pericyte on the endothelial proliferation. It is postulated that the function of the pericyte in the prenatal mammals are assigned to the regulation of the development of cerebral microcirculation.
Authors: Mariel G Kozberg; Brenda R Chen; Sarah E DeLeo; Matthew B Bouchard; Elizabeth M C Hillman Journal: Proc Natl Acad Sci U S A Date: 2013-02-20 Impact factor: 11.205