Laura Beth Payne1, Maruf Hoque1,2, Clifton Houk3,4, Jordan Darden1,2,4, John C Chappell1,3,5. 1. Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech-Carilion, Roanoke, VA 24016, USA. 2. Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, Blacksburg, VA 24061, USA. 3. Virginia Tech Carilion School of Medicine, Roanoke, VA, 24016, USA. 4. Previous Affiliations. 5. Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA 24061, USA.
Abstract
PURPOSE OF REVIEW: Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation. RECENT FINDINGS: Recent advances in pericyte-focused tools and models have illuminated critical aspects of pericyte biology including their roles in vascular development.Pericytes likely collaborate with endothelial cells undergoing vasculogenesis, initiating direct interactions during sprouting and intussusceptive angiogenesis. Pericytes also provide important regulation of vascular growth including mechanisms underlying vessel pruning, rarefaction, and subsequent regrowth.
PURPOSE OF REVIEW: Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation. RECENT FINDINGS: Recent advances in pericyte-focused tools and models have illuminated critical aspects of pericyte biology including their roles in vascular development.Pericytes likely collaborate with endothelial cells undergoing vasculogenesis, initiating direct interactions during sprouting and intussusceptive angiogenesis. Pericytes also provide important regulation of vascular growth including mechanisms underlying vessel pruning, rarefaction, and subsequent regrowth.
Authors: Laura B Payne; Huaning Zhao; Carissa C James; Jordan Darden; David McGuire; Sarah Taylor; James W Smyth; John C Chappell Journal: Microcirculation Date: 2019-05-27 Impact factor: 2.628
Authors: Per Lindblom; Holger Gerhardt; Stefan Liebner; Alexandra Abramsson; Maria Enge; Mats Hellstrom; Gudrun Backstrom; Simon Fredriksson; Ulf Landegren; Henrik C Nystrom; Goran Bergstrom; Elisabetta Dejana; Arne Ostman; Per Lindahl; Christer Betsholtz Journal: Genes Dev Date: 2003-08-01 Impact factor: 11.361
Authors: Alise Zagare; Kyriaki Barmpa; Semra Smajic; Lisa M Smits; Kamil Grzyb; Anne Grünewald; Alexander Skupin; Sarah L Nickels; Jens C Schwamborn Journal: Am J Hum Genet Date: 2022-01-24 Impact factor: 11.025
Authors: Scott S Kemp; Prisca K Lin; Zheying Sun; Maria A Castaño; Ksenia Yrigoin; Marlena R Penn; George E Davis Journal: Front Cell Dev Biol Date: 2022-08-22