Literature DB >> 74852

Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning.

J J Boylan, J L Egle, P S Guzelian.   

Abstract

In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.

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Year:  1978        PMID： 74852     DOI： 10.1126/science.74852

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

Review 1.  Enterohepatic circulation: physiological, pharmacokinetic and clinical implications.

Authors:  Michael S Roberts; Beatrice M Magnusson; Frank J Burczynski; Michael Weiss
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

2.  Disposition of low and high environmental concentrations of PCBs in snapping turtle tissues.

Authors:  A M Bryan; P G Olafsson; W B Stone
Journal:  Bull Environ Contam Toxicol       Date:  1987-06       Impact factor: 2.151

3.  Fate of hexachlorocyclopentadiene in water and goldfish.

Authors:  A A Podowski; M A Khan
Journal:  Arch Environ Contam Toxicol       Date:  1984-07       Impact factor: 2.804

Review 4.  Factors affecting the storage and excretion of toxic lipophilic xenobiotics.

Authors:  R J Jandacek; P Tso
Journal:  Lipids       Date:  2001-12       Impact factor: 1.880

5.  Enteric transport of chlordecone (Kepone) in the rat.

Authors:  P M Bungay; R L Dedrick; H B Matthews
Journal:  J Pharmacokinet Biopharm       Date:  1981-06

6.  Studies on the in vitro binding of D-penicillamine to cholestyramine.

Authors:  H Allgayer; W Kruis; G Paumgartner
Journal:  Experientia       Date:  1982-04-15

7.  Residential and recreational acquisition of possible estuary-associated syndrome: a new approach to successful diagnosis and treatment.

Authors:  R C Shoemaker
Journal:  Environ Health Perspect       Date:  2001-10       Impact factor: 9.031

8.  Possible estuary-associated syndrome: symptoms, vision, and treatment.

Authors:  R C Shoemaker; H K Hudnell
Journal:  Environ Health Perspect       Date:  2001-05       Impact factor: 9.031

Review 9.  A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins.

Authors:  Janette Hope
Journal:  ScientificWorldJournal       Date:  2013-04-18

10.  Intestinal disease and the urban environment.

Authors:  H P Schedl
Journal:  Environ Health Perspect       Date:  1979-12       Impact factor: 9.031
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