Literature DB >> 7084416

Studies on the in vitro binding of D-penicillamine to cholestyramine.

H Allgayer, W Kruis, G Paumgartner.   

Abstract

Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4-8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/l) inhibited this small adsorption by 87%.

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Year:  1982        PMID： 7084416     DOI： 10.1007/BF01952651

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  19 in total

1.  Colorimetric estimation of penicillamine.

Authors:  P R PAL
Journal:  J Biol Chem       Date:  1959-03       Impact factor: 5.157

2.  Effect of D-penicillamine on copper retention in patients with primary billiary cirrhosis.

Authors:  T B Deering; E R Dickson; C R Fleming; M G Geall; J T McCall; A H Baggenstoss
Journal:  Gastroenterology       Date:  1977-06       Impact factor: 22.682

3.  Proceedings: Cholestyramine therapy in cholestatic liver disease of children.

Authors:  R Nelson; G M Murphy; S Edkins; S Nutter; C M Anderson
Journal:  Gut       Date:  1974-10       Impact factor: 23.059

4.  Impairment by cholestyramine of dicumarol and tromexan absorption in rats: a potential drug interaction.

Authors:  A V Tembo; T R Bates
Journal:  J Pharmacol Exp Ther       Date:  1974-10       Impact factor: 4.030

5.  Inhibitory effect of cholestyramine on the absorption of flufenamie and mefenamic acids in rats.

Authors:  H A Rosenberg; T R Bates
Journal:  Proc Soc Exp Biol Med       Date:  1974-01

6.  Effect of cholestyramine on fecal bile salt excretion in rats fed diets containing medium-chain triglycerides or corn oil.

Authors:  L M Hagerman; D L Schneider
Journal:  Proc Soc Exp Biol Med       Date:  1973-05

7.  Drug-cholestyramine interactions. I. Physicochemical factors affecting in vitro binding of sodium fusidate to cholestyramine.

Authors:  W H Johns; T R Bates
Journal:  J Pharm Sci       Date:  1972-05       Impact factor: 3.534

8.  A controlled trial of D-penicillamine therapy in primary biliary cirrhosis.

Authors:  S Jain; P J Scheuer; S Samourian; J O McGee
Journal:  Lancet       Date:  1977-04-16       Impact factor: 79.321

9.  Effect of cholestyramine on bile acid metabolism in normal man.

Authors:  J T Garbutt; T J Kenney
Journal:  J Clin Invest       Date:  1972-11       Impact factor: 14.808

10.  Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.

Authors:  J H Caldwell; N J Greenberger
Journal:  J Clin Invest       Date:  1971-12       Impact factor: 14.808
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  1 in total

1.  Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer.

Authors:  H Allgayer; M Kolb; V Stuber; W Kruis
Journal:  Dig Dis Sci       Date:  1999-04       Impact factor: 3.199
  1 in total

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