INTRODUCTION: We determined the diagnostic accuracy of the Mini-Mental State Examination (MMSE) for dementia of the Alzheimer type (DAT) in an outpatient geriatric referral center in Switzerland. MATERIAL & METHODS: DAT patients and elderly controls were assigned to two groups: a validation sample (70 DAT patients; 50 controls) and a cross-validation sample (133 DAT patients; 43 controls). A Receiver Operating Characteristic curve was generated to derive the optimal MMSE cut-off score in the validation sample. RESULTS: The optimal MMSE cut-off was < 26/30 (sensitivity of 74%, specificity of 100%). Adjustments for age and education were necessary. The cross-validation confirmed these findings. CONCLUSION: iN A clinical setting the MMSE cut-off should be increased to < 26/30. A thorough neurobehavioral assessment is still necessary for a complete evaluation.
INTRODUCTION: We determined the diagnostic accuracy of the Mini-Mental State Examination (MMSE) for dementia of the Alzheimer type (DAT) in an outpatient geriatric referral center in Switzerland. MATERIAL & METHODS:DATpatients and elderly controls were assigned to two groups: a validation sample (70 DATpatients; 50 controls) and a cross-validation sample (133 DATpatients; 43 controls). A Receiver Operating Characteristic curve was generated to derive the optimal MMSE cut-off score in the validation sample. RESULTS: The optimal MMSE cut-off was < 26/30 (sensitivity of 74%, specificity of 100%). Adjustments for age and education were necessary. The cross-validation confirmed these findings. CONCLUSION: iN A clinical setting the MMSE cut-off should be increased to < 26/30. A thorough neurobehavioral assessment is still necessary for a complete evaluation.
Authors: Elizabeth C Leritz; Regina E McGlinchey; Kristine Lundgren; Laura J Grande; William P Milberg Journal: Neuropsychology Date: 2008-11 Impact factor: 3.295
Authors: Elizabeth Guerrero-Berroa; Xiaodong Luo; James Schmeidler; Michael A Rapp; Karen Dahlman; Hillel T Grossman; Vahram Haroutunian; Michal Schnaider Beeri Journal: Int J Geriatr Psychiatry Date: 2009-12 Impact factor: 3.485
Authors: Michael M Ehrensperger; Kirsten I Taylor; Manfred Berres; Nancy S Foldi; Myriam Dellenbach; Irene Bopp; Gabriel Gold; Armin von Gunten; Daniel Inglin; René Müri; Brigitte Rüegger; Reto W Kressig; Andreas U Monsch Journal: Alzheimers Res Ther Date: 2014-11-24 Impact factor: 6.982