Literature DB >> 748358

Metabolism of biphenyl in the rat.

K Halpaap, M G Horning, E C Horning.   

Abstract

The metabolism of biphenyl in the rat has been studied by using gas chromatographic and mass spectrometric methods. The free and conjugated urinary metabolites were characterized. Eight new metabolites were isolated: a dihydrodiol and two hydroxydihydrodiols were characteristic for the epoxide--diol pathway. There were two dihydroxybiphenyls, a trihydroxybiphenyl, a trihydroxymethoxybiphenyl and 4,4'-dihydroxy-3-methylthiobiphenyl. The mass spectra of the trimethylsilyl derivatives of the metabolites exhibited characteristic doubly charged and metastable ions.

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Year:  1978        PMID： 748358     DOI： 10.1016/s0021-9673(00)95631-0

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

1.  Reactive Functionalized Membranes for Polychlorinated Biphenyl Degradation.

Authors:  Minghui Gui; Lindell E Ormsbee; Dibakar Bhattacharyya
Journal:  Ind Eng Chem Res       Date:  2013-08-07       Impact factor: 3.720

2.  Urinary hydroxydiphenyl excretion of workers occupationally exposed to a mixture of diphenyl and diphenylether (Dowtherm A).

Authors:  F O Dorgelo; G Verver; G Wieling; R J Topp; J S Boleij; T M Pal
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

3.  Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.

Authors:  Justine L Delgado; Sarah R C Lentz; Chaitanya A Kulkarni; Pratik R Chheda; Hailey A Held; Hiroshi Hiasa; Robert J Kerns
Journal:  Eur J Med Chem       Date:  2019-03-20       Impact factor: 6.514

4.  The metabolism of 8-methoxypsoralen in man.

Authors:  J Schmid; A Prox; A Reuter; H Zipp; F W Koss
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1980       Impact factor: 2.441

5.  Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155).

Authors:  M R Fielden; I Chen; B Chittim; S H Safe; T R Zacharewski
Journal:  Environ Health Perspect       Date:  1997-11       Impact factor: 9.031
  5 in total

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