Literature DB >> 7481774

Participation of the human beta-globin locus control region in initiation of DNA replication.

M I Aladjem1, M Groudine, L L Brody, E S Dieken, R E Fournier, G M Wahl, E M Epner.   

Abstract

The human beta-globin locus control region (LCR) controls the transcription, chromatin structure, and replication timing of the entire locus. DNA replication was found to initiate in a transcription-independent manner within a region located 50 kilobases downstream of the LCR in human, mouse, and chicken cells containing the entire human beta-globin locus. However, DNA replication did not initiate within a deletion mutant locus lacking the sequences that encompass the LCR. This mutant locus replicated in the 3' to 5' direction. Thus, interactions between distantly separated sequences can be required for replication initiation, and factors mediating this interaction appear to be conserved in evolution.

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Year:  1995        PMID： 7481774     DOI： 10.1126/science.270.5237.815

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  78 in total

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Authors:  Y Ogawa; T Takahashi; H Masukata
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

Authors:  L Lu; H Zhang; J Tower
Journal:  Genes Dev       Date:  2001-01-15       Impact factor: 11.361

3.  The linking regions of EBNA1 are essential for its support of replication and transcription.

Authors:  D Mackey; B Sugden
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

4.  Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region.

Authors:  D M Cimbora; D Schübeler; A Reik; J Hamilton; C Francastel; E M Epner; M Groudine
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

5.  Developmental regulation of DNA replication timing at the human beta globin locus.

Authors:  I Simon; T Tenzen; R Mostoslavsky; E Fibach; L Lande; E Milot; J Gribnau; F Grosveld; P Fraser; H Cedar
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Review 6.  Making sense of eukaryotic DNA replication origins.

Authors:  D M Gilbert
Journal:  Science       Date:  2001-10-05       Impact factor: 47.728

7.  Multiple sites of replication initiation in the human beta-globin gene locus.

Authors:  S Kamath; M Leffak
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971

8.  Differential use of multiple replication origins in the ribosomal DNA episome of the protozoan parasite Entamoeba histolytica.

Authors:  Soma Ghosh; S Satish; Sonika Tyagi; Alok Bhattacharya; Sudha Bhattacharya
Journal:  Nucleic Acids Res       Date:  2003-04-15       Impact factor: 16.971

9.  Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.

Authors:  D A Natale; C J Li; W H Sun; M L DePamphilis
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

Review 10.  DNA replication timing, genome stability and cancer: late and/or delayed DNA replication timing is associated with increased genomic instability.

Authors:  Nathan Donley; Mathew J Thayer
Journal:  Semin Cancer Biol       Date:  2013-01-14       Impact factor: 15.707
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