D A Bluemke1, M Petri, E A Zerhouni. 1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Abstract
PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77% +/- 5 [standard deviation]; healthy subjects, 78% +/- 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min +/- 6 vs 6.9%/min +/- 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy and is higher in SLE patients without hip avascular necrosis.
PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLEpatients, 77% +/- 5 [standard deviation]; healthy subjects, 78% +/- 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min +/- 6 vs 6.9%/min +/- 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy and is higher in SLEpatients without hip avascular necrosis.
Authors: Joe Barfett; Nivethan Velauthapillai; Christian Kloeters; David J Mikulis; Jeffrey D Jaskolka Journal: Int J Cardiovasc Imaging Date: 2012-12 Impact factor: 2.357
Authors: Arda Kayhan; Cheng Yang; Fatma Nur Soylu; Hatice Lakadamyalı; Ila Sethi; Gregory Karczmar; Walter Stadler; Aytekin Oto Journal: World J Radiol Date: 2011-10-28