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Literature DB >> 7474155

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

Abstract

Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7474155 PMCID： PMC189655

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

37 in total

Review 1. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

Authors: M Rodriguez; E Oleszak; J Leibowitz
Journal: Crit Rev Immunol Date: 1987 Impact factor: 2.214

2. Mechanism of Theiler's virus-induced demyelination in nude mice.

Authors: A Rosenthal; R S Fujinami; P W Lampert
Journal: Lab Invest Date: 1986-05 Impact factor: 5.662

3. Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination.

Authors: A Wille; A Gessner; H Lother; F Lehmann-Grube
Journal: Eur J Immunol Date: 1989-07 Impact factor: 5.532

4. Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus.

Authors: C V Paya; A K Patick; P J Leibson; M Rodriguez
Journal: J Immunol Date: 1989-07-01 Impact factor: 5.422

5. Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.

Authors: J F Bureau; X Montagutelli; F Bihl; S Lefebvre; J L Guénet; M Brahic
Journal: Nat Genet Date: 1993-09 Impact factor: 38.330

6. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

Authors: R J Clatch; H L Lipton; S D Miller
Journal: J Immunol Date: 1986-02-01 Impact factor: 5.422

7. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens).

Authors: M Rodriguez; W P Lafuse; J Leibowitz; C S David
Journal: Neurology Date: 1986-07 Impact factor: 9.910

8. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

Authors: H M Cherwinski; J H Schumacher; K D Brown; T R Mosmann
Journal: J Exp Med Date: 1987-11-01 Impact factor: 14.307

Review 9. Multiple sclerosis: basic concepts and hypothesis.

Authors: M Rodriguez
Journal: Mayo Clin Proc Date: 1989-05 Impact factor: 7.616

10. Endogenous gamma interferon produced in central nervous system by systemic infection with Theiler's virus in mice.

Authors: M Kohanawa; A Nakane; T Minagawa
Journal: J Neuroimmunol Date: 1993 Nov-Dec Impact factor: 3.478

28 in total

1. Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 mice.

Authors: Young-Hee Jin; Hyun Seok Kang; Mani Mohindru; Byung S Kim
Journal: J Virol Date: 2010-12-29 Impact factor: 5.103

2. Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination.

Authors: Jason Kerkvliet; Laurie Zoecklein; Louisa Papke; Aleksandar Denic; Allan J Bieber; Larry R Pease; Chella S David; Moses Rodriguez
Journal: J Virol Date: 2009-09-16 Impact factor: 5.103

3. Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus.

Authors: T E Lane; A D Paoletti; M J Buchmeier
Journal: J Virol Date: 1997-03 Impact factor: 5.103

4. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus.

Authors: Ajai A Dandekar; Katherine O'Malley; Stanley Perlman
Journal: J Virol Date: 2005-08 Impact factor: 5.103