Literature DB >> 2827957

Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

M Rodriguez1, E Oleszak, J Leibowitz.   

Abstract

Theiler's murine encephalomyelitis virus (TMEV) causes immune-mediated demyelination in susceptible mice which is similar to human demyelinating disorders such as multiple sclerosis. In addition, the picornavirus persists within the central nervous system throughout the course of the chronic demyelinating disease. This article reviews the neuropathology, virology, immunology, and molecular biology of the model system. We analyze the possible mechanisms by which this virus induces demyelination and persists in the nervous system. Finally, we provide a hypothesis that the specificity of primary white matter destruction in the TMEV model depends on immune-sensitized cells which interact with viral antigen plus major histocompatibility complex (MHC) antigens on the surfaces of oligodendrocytes or myelin sheaths.

Entities:  

Mesh：

Year:  1987        PMID： 2827957

Source DB:  PubMed          Journal:  Crit Rev Immunol        ISSN： 1040-8401            Impact factor:   2.214


  68 in total

1.  Analysis of cellular mutants resistant to Theiler's virus infection: differential infection of L929 cells by persistent and neurovirulent strains.

Authors:  K Jnaoui; T Michiels
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  A coding RNA sequence acts as a replication signal in cardioviruses.

Authors:  P E Lobert; N Escriou; J Ruelle; T Michiels
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

3.  Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis.

Authors:  D B McGavern; P D Murray; C Rivera-Quiñones; J D Schmelzer; P A Low; M Rodriguez
Journal:  Brain       Date:  2000-03       Impact factor: 13.501

4.  The relevance of animal models in multiple sclerosis research.

Authors:  Aleksandar Denic; Aaron J Johnson; Allan J Bieber; Arthur E Warrington; Moses Rodriguez; Istvan Pirko
Journal:  Pathophysiology       Date:  2011-02

5.  Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis.

Authors:  S Sathornsumetee; D B McGavern; D R Ure; M Rodriguez
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

6.  The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.

Authors:  J F Bureau; X Montagutelli; S Lefebvre; J L Guénet; M Pla; M Brahic
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

7.  Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures.

Authors:  Y Ohara; H Konno; Y Iwasaki; T Yamamoto; H Terunuma; H Suzuki
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

8.  Intravenous immunoglobulin therapy in multiple sclerosis: progress from remyelination in the Theiler's virus model to a randomised, double-blind, placebo-controlled clinical trial.

Authors:  J H Noseworthy; P C O'Brien; B G van Engelen; M Rodriguez
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-11       Impact factor: 10.154

9.  Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

Authors:  M Rodriguez; K Pavelko; R L Coffman
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice.

Authors:  R L Yauch; K Kerekes; K Saujani; B S Kim
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103
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