Literature DB >> 7470888

Evidence for a tonic GABAergic control of serotonin neurons in the median raphe nucleus.

C M Forchetti, J L Meek.   

Abstract

We examined whether serotonin (5-HT)-containing neurons of the midbrain raphe nuclei are subject to an inhibitory control by GABA. We found that injection into the median raphe nucleus of the GABA antagonists picrotoxin and bicuculline and the GABA agonist muscimol increase and decrease, respectively, the 5-HT turnover and the steady-state content of 5-hydroxyindoleacetic acid. The results provide evidence of a tonic inhibition by GABA of 5-HT neuronal activity in the median raphe nucleus; this inhibitory effect is potentiated by benzodiazepines.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7470888     DOI： 10.1016/0006-8993(81)90118-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

Review 1.  Serotonergic modulation of hippocampal theta activity in relation to hippocampal information processing.

Authors:  María Esther Olvera-Cortés; Blanca Erika Gutiérrez-Guzmán; Elisa López-Loeza; J Jesús Hernández-Pérez; Miguel Angel López-Vázquez
Journal:  Exp Brain Res       Date:  2013-08-30       Impact factor: 1.972

2.  Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe.

Authors:  Julia C Lemos; Yu-Zhen Pan; Xiaohong Ma; Christophe Lamy; Adaure C Akanwa; Sheryl G Beck
Journal:  Eur J Neurosci       Date:  2006-12       Impact factor: 3.386

3.  Lateral habenula and hippocampus: a complex interaction raphe cells-mediated.

Authors:  G Ferraro; M E Montalbano; P Sardo; V La Grutta
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Differential regulation of 5-hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats.

Authors:  R Tao; Z Ma; S B Auerbach
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

5.  Possible pathogenic mechanisms on trimethyltin-induced lesions in the hippocampus of adult and neonatal rats : An overview.

Authors:  L W Chang
Journal:  Biol Trace Elem Res       Date:  1987-08       Impact factor: 3.738

6.  Asparagus racemosus attenuates anxiety-like behavior in experimental animal models.

Authors:  Debapriya Garabadu; Sairam Krishnamurthy
Journal:  Cell Mol Neurobiol       Date:  2014-02-21       Impact factor: 5.046

7.  Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels.

Authors:  E Mocaër-Cretet; M Prioux-Guyonneau; F Redjimi; Y Cohen; C Jacquot
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-07       Impact factor: 3.000

8.  Studies on the interaction between cerebral 5-hydroxytryptamine and gamma-aminobutyric acid in the mode of action of diazepam in the rat.

Authors:  J Collinge; C J Pycock; P V Taberner
Journal:  Br J Pharmacol       Date:  1983-07       Impact factor: 8.739

9.  Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat.

Authors:  G G Kinney; B Kocsis; R P Vertes
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

10.  Long-lasting changes in regional brain amino acids and monoamines in recovered pyrithiamine treated rats.

Authors:  P J Langlais; R G Mair; C D Anderson; W J McEntee
Journal:  Neurochem Res       Date:  1988-12       Impact factor: 3.996
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.